Betala Jayesh, Bae Sooneon, Langan Eugene M, LaBerge Martine, Lee Jeoung Soo
Department of Bioengineering, Clemson University, SC 29634, USA.
Department of Vascular Surgery, Greenville Health System, Greenville, SC 29615, USA.
Nanomedicine (Lond). 2020 May;15(12):1205-1220. doi: 10.2217/nnm-2020-0028. Epub 2020 Apr 28.
To develop poly(lactide-co-glycolide)-graft-polyethylenimine (PgP) as a dual drug-delivery carrier for sirolimus (SR) and heparin (Hep) to inhibit restenosis after balloon angioplasty. SR was loaded in the hydrophobic core and negatively charged Hep complexed with the positively charged hydrophilic shell of PgP. SR- and Hep-loaded PgP was tested on rat aortic smooth muscle cells and injured porcine coronary arteries after balloon angioplasty . SR and Hep loading efficiency in PgP were approximately 37 and 82%, respectively. SR- and Hep-loaded PgP treatment decreased smooth muscle cell proliferation up to 14 days post-treatment and decreased proliferation, collagen deposition and neointimal thickness and increased patency in porcine coronary arteries after balloon angioplasty .
开发聚（丙交酯-共-乙交酯）-接枝-聚乙烯亚胺（PgP）作为西罗莫司（SR）和肝素（Hep）的双重药物递送载体，以抑制球囊血管成形术后的再狭窄。SR负载于疏水核心中，带负电荷的Hep与带正电荷的PgP亲水性外壳复合。负载SR和Hep的PgP在大鼠主动脉平滑肌细胞和球囊血管成形术后的猪损伤冠状动脉上进行了测试。PgP中SR和Hep的负载效率分别约为37%和82%。负载SR和Hep的PgP治疗在治疗后长达14天降低了平滑肌细胞增殖，并在球囊血管成形术后的猪冠状动脉中降低了增殖、胶原沉积和新生内膜厚度，提高了通畅率。
