分子生物学方法研究脊柱关节炎。
Molecular Biology Approaches to Understanding Spondyloarthritis.
机构信息
Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court Mail Stop B115, Aurora, CO 80045, USA.
Division of Rheumatology, University of Colorado School of Medicine, 1775 Aurora Court Mail Stop B115, Aurora, CO 80045, USA.
出版信息
Rheum Dis Clin North Am. 2020 May;46(2):203-211. doi: 10.1016/j.rdc.2020.01.001.
New and emerging molecular techniques are expanding understanding of the pathophysiology of spondyloarthritis (SpA). Genome-wide association studies identified novel pathways in antigen processing and presentation as well as helper T cell type 17 (T17) immunity associated with SpA. Immune cell profiling techniques have supported T17 immune responses and increasingly are revealing intestinal mucosal immune cells as associated with disease. Emerging technologies in epigenetics, transcriptomics, microbiome, and proteomics/metabolomics are adding to these, refining disease pathways and potentially identifying biomarkers for diagnosis and treatment responses. This review describes many of the new molecular techniques that are being utilized to investigate SpA.
新出现的分子技术正在拓展对脊柱关节炎（SpA）病理生理学的理解。全基因组关联研究确定了与 SpA 相关的抗原加工和呈递以及辅助性 T 细胞 17（T17）免疫的新途径。免疫细胞分析技术支持了 T17 免疫反应，并且越来越多地揭示了与疾病相关的肠道黏膜免疫细胞。表观遗传学、转录组学、微生物组学和蛋白质组学/代谢组学中的新兴技术正在增加这些技术，从而完善疾病途径并可能为诊断和治疗反应确定生物标志物。本综述描述了许多正在用于研究 SpA 的新分子技术。
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