Mangues M A, Bonal J, Farré R, Francesc Massó J
Clinical Pharmacokinetics Section, Hospital Sta. Creu i St. Pau, Barcelona, Spain.
Drug Intell Clin Pharm. 1988 Nov;22(11):893-4. doi: 10.1177/106002808802201114.
Theophylline is widely prescribed in Spain. Because this drug has a narrow therapeutic range and high interindividual pharmacokinetic variability, it is essential to adapt the dosage to each patient. In order to simplify the drug individualization we are proposing three algorithms to apply to intravenous loading and maintenance doses and to oral doses. The initial recommended dosages have been established using the pharmacokinetic parameters obtained from patients treated with theophylline in our hospital. Because the pharmacokinetic behavior of theophylline may be different in other populations, dosage requirements may not be the same. A minimum number of blood sample collections is proposed in an attempt to improve the cost-benefit relationship in theophylline therapy.
在西班牙，茶碱的处方用量广泛。由于这种药物的治疗窗较窄且个体间药代动力学变异性高，因此根据每位患者调整剂量至关重要。为了简化药物个体化，我们提出了三种算法，分别应用于静脉负荷剂量和维持剂量以及口服剂量。初始推荐剂量是利用从我院接受茶碱治疗的患者获得的药代动力学参数确定的。由于茶碱在其他人群中的药代动力学行为可能不同，剂量需求可能也不一样。为了改善茶碱治疗的成本效益关系，建议采集最少数量的血样。
