Fitzpatrick R W, Moss-Barclay C
J Clin Hosp Pharm. 1985 Sep;10(3):279-87. doi: 10.1111/j.1365-2710.1985.tb00925.x.
A pharmacokinetic method for individualizing theophylline dosage is described. The method was shown to be reliable and accurate, and maintained significantly more patients within the optimum therapeutic range when compared with conventional regimens. The study also showed that when conventional dosage regimens are used, a large proportion of patients exhibit theophylline levels well below the optimum therapeutic range. Population pharmacokinetic data for theophylline and the effect of congestive heart failure on its clearance are also presented.
描述了一种用于个体化氨茶碱剂量的药代动力学方法。该方法被证明是可靠且准确的，与传统方案相比，能使更多患者维持在最佳治疗范围内。研究还表明，使用传统剂量方案时，很大一部分患者的氨茶碱水平远低于最佳治疗范围。文中还给出了氨茶碱的群体药代动力学数据以及充血性心力衰竭对其清除率的影响。
