Laboratory of neuroimaging and multimodal analysis, Mental Health Research Center, Moscow, Russia.
International Institute of Psychosomatic Health, Moscow, Russia.
J Int Neuropsychol Soc. 2020 Sep;26(8):749-762. doi: 10.1017/S1355617720000302. Epub 2020 Apr 28.
Goldberg, the author of the "novelty-routinization" framework, suggested a new pair of cognitive styles for agent-centered decision-making (DM), context-dependency/independency (CD/CI), quantified by the Cognitive Bias Task (CBT) and supposedly reflecting functional brain hemispheric specialization. To date, there are only three lesion and activation neuroimaging studies on the CBT with the largest sample of 12 participants. The present study is the first to analyze whole-brain functional connectivity (FC) of the dorsolateral prefrontal cortex (DLPFC), involved in contextual agent-centered DM.
We compared whole-brain resting-state FC of the DLPFC between CD (n = 24) and CI (n = 22) healthy participants. Additionally, we investigated associations between CD/CI and different aspects of executive functions.
CD participants had stronger positive FC of the DLPFC with motor and visual regions; FC of the left DLPFC was more extensive. CI participants had stronger positive FC of the left DLPFC with right prefrontal and parietal-occipital areas and of the left and right DLPFC with ipsilateral cerebellar hemispheres. No sex differences were found. CD/CI had nonlinear associations with working memory.
The findings suggest that CD and CI are associated with different patterns of DLPFC FC. While CD is associated with FC between DLPFC and areas presumably involved in storing representations of current situation, CI is more likely to be associated with FC between DLPFC and right-lateralized associative regions, probably involved in the inhibition of the CD response and switching from processing of incoming perceptual information to creation of original response strategies.
作者戈德堡提出了一种新的认知风格，即“新颖性-常规化”框架，用于代理中心决策（DM），以认知偏差任务（CBT）量化的情境依存性/独立性（CD/CI），并假定反映了功能性大脑半球专门化。迄今为止，只有三项关于 CBT 的病变和激活神经影像学研究，最大样本量为 12 名参与者。本研究首次分析了参与情境代理中心 DM 的背外侧前额叶皮层（DLPFC）的全脑功能连接（FC）。
我们比较了 CD（n = 24）和 CI（n = 22）健康参与者的 DLPFC 全脑静息状态 FC。此外，我们还研究了 CD/CI 与不同执行功能方面之间的关联。
CD 参与者的 DLPFC 与运动和视觉区域的正 FC 更强；左 DLPFC 的 FC 更广泛。CI 参与者的左 DLPFC 与右侧前额叶和顶枕叶区域以及左右 DLPFC 与同侧小脑半球的正 FC 更强。未发现性别差异。CD/CI 与工作记忆呈非线性关联。
研究结果表明，CD 和 CI 与 DLPFC FC 的不同模式相关。虽然 CD 与 DLPFC 与假定参与当前情况表示存储的区域之间的 FC 相关，CI 更可能与 DLPFC 与右侧关联区域之间的 FC 相关，可能涉及抑制 CD 反应和从处理传入的感知信息转换为创建原始反应策略。
