Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.
Program in Metabolic Biology, Nutritional Sciences & Toxicology, University of California, Berkeley, CA 94720, USA.
Mech Ageing Dev. 2020 Jun;188:111254. doi: 10.1016/j.mad.2020.111254. Epub 2020 Apr 25.
Stem cell aging contributes to aging-associated tissue degeneration and dysfunction. Recent studies reveal a mitochondrial metabolic checkpoint that regulates stem cell quiescence and maintenance, and dysregulation of the checkpoint leads to functional deterioration of aged stem cells. Here, we present the evidence supporting the mitochondrial metabolic checkpoint regulating stem cell aging and demonstrating the feasibility to target this checkpoint to reverse stem cell aging. We discuss the mechanisms by which mitochondrial stress leads to stem cell deterioration. We speculate the therapeutic potential of targeting the mitochondrial metabolic checkpoint for rejuvenating aged stem cells and improving aging tissue functions.
干细胞衰老导致与衰老相关的组织退化和功能障碍。最近的研究揭示了一个线粒体代谢检查点，它调节干细胞静止和维持，而检查点的失调导致衰老干细胞功能恶化。在这里，我们提供了支持调节干细胞衰老的线粒体代谢检查点的证据，并证明了靶向该检查点以逆转干细胞衰老的可行性。我们讨论了线粒体应激导致干细胞恶化的机制。我们推测，靶向线粒体代谢检查点为衰老干细胞恢复活力和改善衰老组织功能的治疗潜力。
