Drug Delivery, Disposition and Dynamics, Monash Institute of Pharmaceutical Sciences, Monash University, 381 Royal Parade, Parkville 3052, Victoria, Australia; Commonwealth Scientific and Industrial Research Organization (CSIRO) Manufacturing, Clayton, VIC 3168, Australia.
Department of Chemical Engineering, Faculty of Engineering, Monash University, Clayton 3800, Victoria, Australia.
J Colloid Interface Sci. 2020 Sep 1;575:24-34. doi: 10.1016/j.jcis.2020.04.081. Epub 2020 Apr 21.
Nanotechnology's rapid development of nanostructured materials with disruptive material properties has inspired research for their use as electrocatalysts to potentially substitute enzymes. Herein, a novel electrocatalytic nanomaterial was constructed by growing gold nanograss (AuNG) on 2D nanoassemblies of gold nanocubes (AuNC). The resulting structure (NG@NC) was used for the detection of HOvia its electrochemical reduction. The NG@NC electrode displayed a large active surface area, resulting in improved electron transfer efficiency. On the nanoscale, AuNG maintained its structure, providing high stability and reproducibility of the sensing platform. Our nanostructured electrode showed excellent catalytic activity towards HO at an applied potential of -0.5 V vs Ag/AgCl. This facilitated HO detection with excellent selectivity in an environment like human urine, and a linear response from 50 µM to 30 mM, with a sensitivity of 100.66 ± 4.0 μA mM cm. The NG@NC-based sensor hence shows great potential in nonenzymatic electrochemical sensing.
纳米技术的快速发展使得具有颠覆性材料特性的纳米结构材料的研究受到启发，将其作为电催化剂来潜在替代酶。在此，通过在二维纳米金纳米立方体（AuNC）组装体上生长金纳米草（AuNG）构建了一种新型电催化纳米材料。所得结构（NG@NC）用于通过电化学还原检测 HO。NG@NC 电极具有较大的有效表面积，从而提高了电子转移效率。在纳米尺度上，AuNG 保持其结构，为传感平台提供了高稳定性和重现性。我们的纳米结构电极在相对于 Ag/AgCl 的 -0.5 V 施加电势下对 HO 表现出优异的催化活性。这使得在类似人体尿液的环境中能够进行优异选择性的 HO 检测，并且在 50 μM 至 30 mM 的线性响应范围内具有 100.66 ± 4.0 μA mM cm 的灵敏度。因此，基于 NG@NC 的传感器在非酶电化学传感中具有很大的潜力。
