Division of Physical Biology, Shanghai Institute of Applied Physics, Chinese Academy of Sciences , Shanghai 201800, China.
ACS Appl Mater Interfaces. 2017 Apr 12;9(14):12773-12781. doi: 10.1021/acsami.7b01141. Epub 2017 Mar 30.
Herein, an electrochemical detection platform was designed based on a Prussian blue nanocube-decorated molybdenum disulfide (MoS-PBNCs) nanocomposite. Shape-controlled and high-dispersion PBNCs were supported on the MoS nanosheet surface, which would be simply controlled by varying the experimental conditions. Expectedly, such obtained MoS-based nanocomposites possessed excellent electrocatalytic ability, which could be employed to construct an electrochemical sensor for nonenzymatic hydrogen peroxide (HO) detection. More interestingly, MoS-PBNCs nanocomposites could be utilized to construct a sensor for label-free detection of carcinoembryonic antigen (CEA). The electrochemical response of the MoS-based immunosensor was linear with the CEA concentration ranging from 0.005 to 10 ng mL. Moreover, the detection limit was calculated to be 0.54 pg mL. The acceptable selectivity and high stability made such immunosensors detect CEA in human serum with satisfactory results. All data indicated that this MoS-PBNCs nanocomposite may be a promising electrochemical sensing platform for the detection of chemical and biological molecules.
本文设计了一种基于普鲁士蓝纳米立方修饰的二硫化钼（MoS-PBNCs）纳米复合材料的电化学检测平台。通过改变实验条件，可以简单地控制在 MoS 纳米片表面支撑形状可控和高分散的 PBNCs。预期得到的基于 MoS 的纳米复合材料具有优异的电催化能力，可用于构建用于非酶过氧化氢（HO）检测的电化学传感器。更有趣的是，MoS-PBNCs 纳米复合材料可用于构建用于无标记癌胚抗原（CEA）检测的传感器。基于 MoS 的免疫传感器的电化学响应与 CEA 浓度在 0.005 至 10ng mL 范围内呈线性关系。此外，检测限计算为 0.54pg mL。该免疫传感器具有可接受的选择性和高稳定性，可用于检测人血清中的 CEA，结果令人满意。所有数据表明，这种 MoS-PBNCs 纳米复合材料可能是用于检测化学和生物分子的有前途的电化学传感平台。
