The Nethersole School of Nursing, Faculty of Medicine, The Chinese University of Hong Kong, Hong Kong, China.
Department of Psychology, The University of British Columbia, Vancouver, BC V6T 1Z4, Canada.
Int J Environ Res Public Health. 2020 Apr 24;17(8):2950. doi: 10.3390/ijerph17082950.
Breast cancer survivors need to undergo adjuvant endocrine therapy after completion of curative treatments to prevent disease recurrence. These individuals often experience symptoms which are detrimental to their quality of life (QOL). Implementation of interventions for effective symptom management among these survivors is warranted. This review provides an overview of studies on the effectiveness of the previously developed interventions for breast cancer survivors undergoing adjuvant endocrine therapy on symptom alleviation and enhancement of QOL or health-related QOL (HRQOL). Five electronic databases were employed in the literature search. Study selection, data extraction and critical appraisal of the included studies were conducted by three authors independently. Twenty-four studies were included. Both pharmacological and non-pharmacological interventions are effective in addressing the symptoms associated with adjuvant endocrine therapy among the breast cancer survivors, and in improving their QOL, although discrepancies were noted between the studies in terms of the significance of these effects. Pharmacological and non-pharmacological interventions can be effective for symptom management among breast cancer survivors. Their implementation is recommended for effective survivorship care for these individuals. Further research on intervention development for breast cancer survivors is recommended to provide further evidence for the utility of the explored interventions in survivorship care for these patients.
乳腺癌幸存者在完成根治性治疗后需要接受辅助内分泌治疗，以预防疾病复发。这些患者常经历对生活质量（QOL）有害的症状。因此，有必要对这些幸存者实施有效的症状管理干预措施。本综述概述了先前为接受辅助内分泌治疗的乳腺癌幸存者开发的干预措施在缓解症状和提高生活质量（QOL）或健康相关生活质量（HRQOL）方面的有效性研究。我们在文献检索中使用了五个电子数据库。由三位作者独立进行研究选择、数据提取和纳入研究的批判性评价。共纳入 24 项研究。药物和非药物干预措施均能有效缓解乳腺癌幸存者接受辅助内分泌治疗后的相关症状，并改善其 QOL，但这些研究在这些效果的显著性方面存在差异。药物和非药物干预措施可有效管理乳腺癌幸存者的症状。建议对这些措施进行实施，以便为这些患者提供有效的生存护理。建议进一步开展针对乳腺癌幸存者的干预措施研究，为探索性干预措施在这些患者的生存护理中的应用提供更多证据。
