Maria Paz Ventero, Servicio Microbiología. Hospital General Universitario de Alicante. Instituto de Investigación, Biomédica y Sanitaria de Alicante (ISABIAL). C/ Pintor Baeza 10. 03010, Alicante, Spain.
Rev Esp Quimioter. 2020 Jun;33(3):200-206. doi: 10.37201/req/024.2020. Epub 2020 Apr 29.
Bloodstream Infections has become in one of the priorities for the antimicrobial stewardship teams due to their high mortality and morbidity rates. Usually, the first antibiotic treatment for this pathology must be empirical, without microbiology data about the microorganism involved. For this reason, the population studies about the etiology of bacteremia are a key factor to improve the selection of the empirical treatment, because they describe the main microorganisms associated to this pathology in each area, and this data could facilitate the selection of correct antibiotic therapy.
This study describes the etiology of bloodstream infections in the Southeast of Spain. The etiology of bacteremia was analysed by a retrospective review of all age-ranged patients from every public hospital in the Autonomous Community of Valencia (approximately 5,000,000 inhabitants) for five years.
A total of 92,097 isolates were obtained, 44.5% of them were coagulase-negative staphylococci. Enterobacteriales was the most prevalent group and an increase in frequency was observed along the time. Streptococcus spp. were the second microorganisms more frequently isolated. Next, the most prevalent were Staphylococcus aureus and Enterococcus spp., both with a stable incidence along the study. Finally, Pseudomonas aeruginosa was the fifth microorganism more frequently solated.
These data constitute a useful tool that can help in the choice of empirical treatment for bloodstream infections, since the knowledge of local epidemiology is key to prescribe a fast and appropriate antibiotic therapy, aspect capital to improve survival.
血流感染已成为抗菌药物管理团队的优先事项之一，因为其具有较高的死亡率和发病率。通常，这种疾病的一线抗生素治疗必须是经验性的，而没有涉及的微生物的微生物学数据。因此，血流感染病因的人群研究是改善经验性治疗选择的关键因素，因为它们描述了每个地区与该疾病相关的主要微生物，并且这些数据可以促进正确的抗生素治疗选择。
本研究描述了西班牙东南部血流感染的病因。通过对瓦伦西亚自治区（约 500 万居民）所有年龄段的所有公立医院患者进行五年的回顾性研究，分析了菌血症的病因。
共获得 92097 株分离株，其中 44.5%为凝固酶阴性葡萄球菌。肠杆菌科是最常见的群组，并且随着时间的推移观察到频率增加。链球菌属是第二常见的分离微生物。其次，最常见的是金黄色葡萄球菌和肠球菌属，两者在研究期间的发病率都保持稳定。最后，铜绿假单胞菌是第五种最常分离的微生物。
这些数据构成了一个有用的工具，可以帮助选择血流感染的经验性治疗，因为了解当地的流行病学知识是快速和适当的抗生素治疗的关键，这是提高生存率的关键。
