Newcomb G M, McKellar G M, Rawal B D
J Periodontol. 1977 May;48(5):282-4. doi: 10.1902/jop.1977.48.5.282.
A double blind clinical trial was conducted in which both the plaque-inhibiting ability and the in vivo effects on the oral flora of chlorhexidine and picloxydine mouthwashes was compared. While picloxydine in higher concentration suppressed the oral flora more effectively than chlorhexidine, the latter agent inhibited plaque development to a much greater extent. This lack of correlation between antibacterial and antiplaque activity can be related to structural differences between these two bis-biguanides.
进行了一项双盲临床试验，比较了洗必泰和吡氯定漱口水的菌斑抑制能力以及对口腔菌群的体内影响。虽然高浓度的吡氯定比洗必泰更有效地抑制口腔菌群，但后者在更大程度上抑制了菌斑的形成。抗菌活性和抗菌斑活性之间的这种缺乏相关性可能与这两种双胍类药物的结构差异有关。
