Key Laboratory of Horticultural Plant Biology (MOE), College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, Hubei Province, PR China.
Key Laboratory of Horticultural Plant Biology (MOE), College of Horticulture and Forestry Sciences, Huazhong Agricultural University, Wuhan 430070, Hubei Province, PR China.
Trends Plant Sci. 2020 Sep;25(9):850-858. doi: 10.1016/j.tplants.2020.03.011. Epub 2020 Apr 25.
At the subcellular level, the cytoskeleton regulates cell structure, organelle movement, and cytoplasmic streaming. Autophagy is a process to remove unwanted biomaterials or damaged organelles through double membrane compartments known as autophagosomes. Autophagosome biogenesis requires vesicle trafficking between donor and acceptor compartments, membrane expansion, and fusion, which is very likely to be regulated by the cytoskeleton. Recent studies have demonstrated that by knocking out key actin-regulating proteins, autophagosome biogenesis is inhibited. However, the formation of ATG8 positive structures are not affected when the entire actin network is disrupted. Here, we discuss this paradox and propose the function of the actin cytoskeleton in plant autophagy.
在亚细胞水平上，细胞骨架调节细胞结构、细胞器运动和细胞质流动。自噬是一种通过称为自噬体的双层膜隔室来去除不需要的生物材料或受损细胞器的过程。自噬体生物发生需要供体和受体隔室之间的囊泡运输、膜扩展和融合，这很可能受到细胞骨架的调节。最近的研究表明，通过敲除关键的肌动蛋白调节蛋白，自噬体生物发生被抑制。然而，当整个肌动蛋白网络被破坏时，ATG8 阳性结构的形成不受影响。在这里，我们讨论了这个悖论，并提出了肌动蛋白细胞骨架在植物自噬中的功能。
