Gabryelewicz A, Prokopowicz J, Bodzenta A, Bielecki W, Rydzewska G
Department of Gastroenterology, Clinical Diagnostics and Hematology, Medical Academy, Bialystok, Poland.
Digestion. 1988;40(1):19-24. doi: 10.1159/000199638.
In 1981, a new low-molecular-weight protease inhibitor, FUT-175 (nafamstat mesilate), was synthesized. Its preventive action against acute experimental pancreatitis (AEP) was detected. We studied the effect of FUT-175 on the blood count and aggregability of platelets in AEP in dogs. At 30 min after induction of AEP, the sensitivity to ADP increased more than two times in untreated animals. An evident decrease in platelet count of about 37% was noted in these dogs at 6 h after AEP induction. Treatment of AEP with FUT-175 prevented these changes. We assume that the positive effect of FUT-175 against AEP depends at least in part on its influence on platelet aggregation.
1981年，一种新型低分子量蛋白酶抑制剂FUT-175（甲磺酸萘莫司他）被合成出来。检测了其对急性实验性胰腺炎（AEP）的预防作用。我们研究了FUT-175对犬急性实验性胰腺炎时血液计数及血小板聚集性的影响。在诱导急性实验性胰腺炎后30分钟，未治疗动物对二磷酸腺苷（ADP）的敏感性增加了两倍多。在诱导急性实验性胰腺炎后6小时，这些犬的血小板计数明显下降了约37%。用FUT-175治疗急性实验性胰腺炎可防止这些变化。我们认为，FUT-175对急性实验性胰腺炎的积极作用至少部分取决于其对血小板聚集的影响。
