McCarthy Kate, Avent Minyon
Royal Brisbane and Women's Hospital, Brisbane.
Pathology Queensland, Brisbane.
Aust Prescr. 2020 Apr;43(2):45-48. doi: 10.18773/austprescr.2020.008. Epub 2020 Apr 1.
Intravenous antibiotics are overused in hospitals. Many infections can be managed with oral antibiotics Oral antibiotics avoid the adverse effects of intravenous administration. They are also usually less expensive When intravenous antibiotics are indicated, it may be possible to switch to oral therapy after a short course. There are guidelines to aid the clinician with the timing of the switch so that there is no loss of efficacy Infections that may be suitable for a short course of intravenous antibiotic include pneumonia, complicated urinary tract infections, certain intra-abdominal infections, Gram-negative bacteraemia, acute exacerbations of chronic lung disease, and skin and soft tissue infections Bone and joint infections and infective endocarditis are managed with prolonged courses of intravenous antibiotics. However, there is research looking at the feasibility of an earlier switch to oral antibiotics in these conditions
静脉用抗生素在医院中被过度使用。许多感染可用口服抗生素治疗。口服抗生素可避免静脉给药的不良反应。它们通常也更便宜。当需要使用静脉用抗生素时,经过短疗程后有可能改用口服疗法。有相关指南可帮助临床医生确定换药时机,以确保疗效不受影响。适合短疗程静脉用抗生素治疗的感染包括肺炎、复杂性尿路感染、某些腹腔内感染、革兰氏阴性菌血症、慢性肺病急性加重以及皮肤和软组织感染。骨和关节感染以及感染性心内膜炎则需用较长疗程的静脉用抗生素治疗。然而,目前有研究探讨在这些情况下更早改用口服抗生素的可行性。