Bao Lei, Li Qing, Li Qingjie, Chen Hao, Zhang Ruixue, Shi Hongjuan, Cui Guiyun
Department of Neurology, The Affiliated Hospital of Xuzhou Medical University, Xuzhou, Jiangsu 221004, People's Republic of China.
Neuropsychiatr Dis Treat. 2020 Apr 15;16:977-984. doi: 10.2147/NDT.S236939. eCollection 2020.
We summarized the clinical manifestations, laboratory and electrodiagnostic characteristics and magnetic resonance imaging (MRI) findings of nitrous oxide (NO) abuse-induced neurological disorders.
We retrospectively reviewed 33 patients with NO abuse-induced neurological disorders and reported their demographic data, clinical manifestations, laboratory examinations, nerve conduction studies, together with spinal and brain MRI.
The most frequent clinical manifestations included numbness and weakness in the extremities and unspecified gait disturbance. Low serum vitamin B levels were found in 9 patients, and high homocysteine levels were noted in 27 patients. Nerve conduction studies showed a sensory-motor neuropathy. Sixteen patients showed bilateral high-intensity T2 signal within the posterior column on spinal MRI, and four patients showed cerebral white matter lesions on brain MRI.
NO abuse has become a significant public health problem because of the severe neurological disorders related to chronic abuse. Clinical physicians should be aware of the toxic effects of NO.
我们总结了一氧化二氮（NO）滥用所致神经障碍的临床表现、实验室及电诊断特征以及磁共振成像（MRI）表现。
我们回顾性分析了33例NO滥用所致神经障碍患者，并报告了他们的人口统计学数据、临床表现、实验室检查、神经传导研究结果以及脊柱和脑部MRI检查结果。
最常见的临床表现包括肢体麻木和无力以及未明确的步态障碍。9例患者血清维生素B水平较低，27例患者同型半胱氨酸水平较高。神经传导研究显示为感觉运动性神经病变。16例患者脊柱MRI显示后柱内双侧T2高信号，4例患者脑部MRI显示脑白质病变。
由于与慢性滥用相关的严重神经障碍，NO滥用已成为一个重大的公共卫生问题。临床医生应意识到NO的毒性作用。
