Badshah Amit, Aijaz Abir, Bhat Abdul, Babar Ayesha
Acute and General Internal Medicine, Weston General Hospital, University Hospitals Bristol and Weston, Weston-super-Mare, GBR.
Acute Medicine, Weston General Hospital, University Hospitals Bristol and Weston, Weston-super-Mare, GBR.
Cureus. 2025 Jun 6;17(6):e85467. doi: 10.7759/cureus.85467. eCollection 2025 Jun.
Nitrous oxide (N₂O) is an uncommon cause of subacute combined degeneration (SCD) of the spinal cord, typically observed in district general hospitals, with most affected patients being male. A genetic predisposition may contribute to the development of this myelopathy, particularly due to polymorphisms in the gene responsible for vitamin B12 processing. Our case is distinct in its presentation, involving prolonged exposure over two years, thoracic dorsal column involvement, and rapid, significant recovery within two months.
一氧化二氮（N₂O）是脊髓亚急性联合变性（SCD）的一种罕见病因，通常在地区综合医院可见，大多数受影响患者为男性。遗传易感性可能促成这种脊髓病的发生，尤其是由于负责维生素B12代谢的基因存在多态性。我们的病例在表现上独具特色，包括长达两年的长期接触、胸段脊髓后柱受累，以及在两个月内迅速且显著恢复。
