Department of Organic Chemistry, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
Department of Pharmaceutical Organization and Legislation, Faculty of Pharmacy, "Iuliu Haţieganu" University of Medicine and Pharmacy, Cluj-Napoca, Romania.
J Sep Sci. 2020 Jul;43(14):2784-2793. doi: 10.1002/jssc.202000262. Epub 2020 May 25.
Reversed-phase thin-layer chromatography and reversed-phase high-performance liquid chromatography were used for lipophilicity determination of a library of 30 thiazole chalcones and aurones previously synthetized in our laboratory. The experimental lipophilicity data have been compared with theoretical lipophilicity parameters estimated by various computational methods. Good correlations between the experimental and calculated lipophilicity parameters have been found for both investigated classes of compounds. Correlations between the lipophilicity of the thiazole chalcones and aurones and their antiproliferative activity were discussed. The methodologies and data gathered in this study will contribute to the lipophilicity studies of chalcones and aurones derivatives, two important classes of compounds in medicinal chemistry.
反相薄层色谱法和反相高效液相色谱法用于测定本实验室先前合成的 30 个噻唑查耳酮和奥rone 的亲脂性。将实验亲脂性数据与通过各种计算方法估算的理论亲脂性参数进行了比较。对于这两种研究的化合物类别，都发现了实验和计算亲脂性参数之间的良好相关性。讨论了噻唑查耳酮和奥rone的亲脂性与其抗增殖活性之间的关系。本研究中收集的方法和数据将有助于查耳酮和奥rone衍生物的亲脂性研究，这是药物化学中两个重要的化合物类别。
