Centro de Investigación Veterinaria de Tandil (CIVETAN)-CONICET, Facultad de Ciencias Veterinarias, Universidad Nacional del Centro de la Provincia de Buenos Aires, Paraje Arroyo Seco S/N, 7000, Tandil, Argentina.
Consejo Nacional de Investigaciones Científicas y Técnicas (CONICET), Rivadavia 1917, C1033AAJ, Buenos Aires, Argentina.
Mol Biol Rep. 2020 Jun;47(6):4905-4909. doi: 10.1007/s11033-020-05449-9. Epub 2020 Apr 28.
Bovine herpevsirus 4 (BoHV-4) is a gammaherpesvirus that has been associated with different clinical conditions in cattle. In Argentina, BoHV-4 was detected in diverse bovine samples. The aim of this study was to analyze the genetic relationship of 48 field BoHV-4 strains isolated from cattle in Argentina. According to thymidine kinase (tk) gene sequences, BoHV-4 isolates belong to genotypes 1, 2 and 3. Phylogenetic analyses confirmed the presence of the three previously described viral genotypes. However, some of the studied isolates presented conflicting phylogenetic signals between the studied markers. This suggests a complex evolutionary background, that is a history of recombination, incomplete lineage sorting (deep coalescence) or a combination of these, which requires further study. These potential events make difficult the diagnosis of BoHV-4 from clinical samples of cattle and may pose a significant problem for the control of the virus in the herds.
牛疱疹病毒 4 型（BoHV-4）是一种γ疱疹病毒，与牛的不同临床病症有关。在阿根廷，已在多种牛样本中检测到 BoHV-4。本研究旨在分析从阿根廷牛中分离的 48 株田间 BoHV-4 分离株的遗传关系。根据胸苷激酶（tk）基因序列，BoHV-4 分离株属于基因型 1、2 和 3。系统进化分析证实了先前描述的三种病毒基因型的存在。然而，一些研究的分离株在研究的标记物之间表现出相互矛盾的系统进化信号。这表明存在复杂的进化背景，即重组、不完全谱系分选（深合并）或它们的组合，这需要进一步研究。这些潜在的事件使得从牛的临床样本中诊断 BoHV-4 变得困难，并且可能对牛群中病毒的控制构成重大问题。
