Serebrianyĭ A M, Sal'nikova L E, Bakhitova L M, Pashin Iu V
Genetika. 1988 Oct;24(10):1786-94.
Significance of carbamoylation for mutagenic effects of N-nitroso-N-methyl-urea (NMU) on the CHO-AT3-2 cell line of Chinese hamster was studied. True point mutations occurred, due to alkylation. Carbamoylation combined with alkylation, or carbamoylation after alkylation induced the increase in other types of gene mutations as well as micro- and macroaberrations. These effects may be explained by the synergistic effect of alkylation and carbamoylation. Possible mechanisms and levels of interaction between alkylation and carbamoylation are discussed.
研究了氨甲酰化对N-亚硝基-N-甲基脲（NMU）对中国仓鼠CHO-AT3-2细胞系诱变作用的意义。由于烷基化发生了真正的点突变。氨甲酰化与烷基化结合，或烷基化后进行氨甲酰化，均诱导了其他类型基因突变以及微核和染色体畸变的增加。这些效应可能由烷基化和氨甲酰化的协同作用来解释。讨论了烷基化和氨甲酰化之间可能的作用机制和相互作用水平。
