Pashin Iu V, Sal'nikova L E, Kozachenko V I
Genetika. 1987 Dec;23(12):2268-71.
The mutagenic effect of short- and long-term MNU exposition causing alkylation and that combined with carbamoylation, correspondingly, at the four specific gene loci of the CHO-AT3-2 Chinese hamster line was studied. The increase both in MNU mutagenic effects and in the range of induced changes resulted from intensification of carbamoylating processes. True point mutations occurred mainly on alkylation. When carbamoylation is increased, the quantity and variety of mutations change towards accumulation of the number of other genetic lesions, for example, frameshift mutations and deletions.
研究了短期和长期接触甲基亚硝基脲（MNU）导致烷基化以及与氨甲酰化相结合时，对中国仓鼠CHO-AT3-2细胞系四个特定基因位点的诱变作用。MNU诱变效应的增加以及诱导变化范围的扩大是由氨甲酰化过程的强化所致。真正的点突变主要发生在烷基化时。当氨甲酰化增加时，突变的数量和种类会朝着其他遗传损伤数量的积累方向变化，例如移码突变和缺失。
