Iakubovskaia E L, Makedonov G P, Zasukhina G D
Genetika. 1988 Nov;24(11):2050-5.
It was shown that pretreatment of human cells with interferons (IF) of different origin has an unequal protective effect under the action of various mutagens with different activity. The protective effect of IF was estimated using the test of sister chromatid exchanges. Natural leucocyte alpha IF is highly effective in healthy human cells and in those of patients having Marfan syndrome. The latter are characterised by disorder in DNA repair under the action of 4-nitroquinoline-1-oxide (4-NQO), 8-methoxypsoralen and gamma-rays. Recombinant interferon (alpha 2) displayed no activity against gamma-rays in cells of healthy donors and patients with Marfan syndrome. Nor was it effective in the cells of patients in the experiments with 4-NQO. The absence of correlation between the ability of IF to protect the cells and their influence on the rate of cell proliferations was established.
结果表明，用不同来源的干扰素（IF）对人体细胞进行预处理，在不同活性的各种诱变剂作用下，具有不等的保护作用。IF的保护作用通过姐妹染色单体交换试验进行评估。天然白细胞α-IF在健康人体细胞和患有马凡综合征的患者细胞中非常有效。后者的特征是在4-硝基喹啉-1-氧化物（4-NQO）、8-甲氧基补骨脂素和γ射线作用下DNA修复紊乱。重组干扰素（α2）在健康供体和马凡综合征患者的细胞中对γ射线无活性。在4-NQO实验中，它在患者细胞中也无效。IF保护细胞的能力与其对细胞增殖速率的影响之间不存在相关性。
