Iakubovskaia E L, Makedonov G P, Kolonina I V, Solopov S A
Radiats Biol Radioecol. 1993 Sep-Oct;33(5):665-73.
A study was made of the antimutagenic effect of natural lymphoblastoid interferon and alpha 2-recombinant interferon against initial damages to DNA induced by 8-methoxypsoralen, activated by UV-light, in human peripheral blood. The crosslinking and uncrosslinking 8-methoxypsoralen monoadducts were shown to make different contribution to the biological effects in cells, that is, chromosome aberrations and sister chromatid exchanges. Both of the investigated interferons exhibited their protective effect with respect to crosslinking monoadducts only. The antimutagenic action of interferon was implemented by a non-repair way. It is suggested that the scavenging of active radicals is a possible mechanism of the protective action of interferon.
对天然淋巴母细胞干扰素和α2重组干扰素针对8-甲氧基补骨脂素经紫外线激活后在人外周血中诱导的DNA初始损伤的抗诱变作用进行了研究。结果表明，交联和非交联的8-甲氧基补骨脂素单加合物对细胞中的生物学效应（即染色体畸变和姐妹染色单体交换）有不同贡献。所研究的两种干扰素仅对交联单加合物表现出保护作用。干扰素的抗诱变作用通过非修复方式实现。提示清除活性自由基可能是干扰素发挥保护作用的机制。
