Ophthalmic Surg Lasers Imaging Retina. 2020 Apr 1;51(4):S30-S36. doi: 10.3928/23258160-20200401-04.
To compare optical coherence tomography angiography (OCTA) capillary perfusion density (CPD) measurements of normal eyes and eyes with macular ischemia (MI).
AVATAR is an institutional review board-approved, prospective, observational imaging study using the Avanti RTVue XR HD. OCTA reports were reviewed for the presence of MI. Qualitative MI grading was performed, and CPD metrics in the superficial and deep fovea and parafovea were analyzed. A normal eye cohort was identified for comparative assessment.
The MI and normal cohorts included 55 and 58 eyes, respectively. Compared to normal eyes, eyes with MI had significantly lower CPD values in all regions. There was a statistically significant correlation between qualitative MI grade and VA in the superficial (P = .003) and deep plexuses (P = .029). Only deep parafoveal CPD values demonstrated correlation with VA (P = .043).
Eyes with MI determined by masked qualitative OCTA grading demonstrated significantly reduced CPD values compared to normal eyes. Categorical assessment of MI severity correlated with VA. [Ophthalmic Surg Lasers Imaging Retina. 2020;51:S30-S36.].
比较正常眼和黄斑缺血（MI）眼中光学相干断层扫描血管造影（OCTA）毛细血管灌注密度（CPD）的测量值。
AVATAR 是一项机构审查委员会批准的、前瞻性、观察性成像研究，使用的是 Avanti RTVue XR HD。对 OCTA 报告进行了分析，以确定是否存在 MI。对定性 MI 分级进行了评估，并分析了浅层、深层和旁中心凹的 CPD 指标。确定了一个正常眼队列进行比较评估。
MI 组和正常组分别包括 55 只眼和 58 只眼。与正常眼相比，MI 眼中所有区域的 CPD 值均显著降低。浅层（P =.003）和深层（P =.029）脉络膜 OCTA 中定性 MI 分级与 VA 之间存在统计学显著相关性。只有深层旁中心凹 CPD 值与 VA 具有相关性（P =.043）。
通过掩蔽定性 OCTA 分级确定的 MI 眼与正常眼相比，CPD 值显著降低。MI 严重程度的分类评估与 VA 相关。[眼科手术激光成像视网膜。2020;51：S30-S36。]
