Human Biology & Basic Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Human Biology & Basic Sciences Divisions, Fred Hutchinson Cancer Research Center, Seattle, WA 98109, USA.
Trends Cancer. 2020 May;6(5):359-361. doi: 10.1016/j.trecan.2020.02.012. Epub 2020 Mar 6.
Lactate dehydrogenase (LDH) accounts for the fermentative component of aerobic glycolysis, a near ubiquitous metabolic alteration in cancer. Recently, Oshima et al. developed a bioavailable LDH inhibitor that decreases tumor growth in mice and functions synergistically with mitochondrial respiration inhibitors. These findings suggest a cooperative mechanism of action that targets redox homeostasis.
乳酸脱氢酶（LDH）是有氧糖酵解的发酵组成部分，是癌症中一种普遍存在的代谢改变。最近，Oshima 等人开发了一种生物可利用的 LDH 抑制剂，可减少小鼠肿瘤生长，并与线粒体呼吸抑制剂协同作用。这些发现表明了一种针对氧化还原平衡的协同作用机制。
