Department of Biology and Biochemistry, University of Bath, Claverton Down, Bath BA2 7AY, UK.
Trends Cancer. 2020 May;6(5):365-368. doi: 10.1016/j.trecan.2020.02.009. Epub 2020 Mar 13.
The major molecular mode of action of the cytotoxic drug 5-fluorouracil (5-FU) is generally considered to result from thymidylate synthase inhibition. Recent findings relating to the function of the human uracil-5 methyltransferase (U5MT), TRMT2A, and its interaction with 5-FU metabolites incorporated within tRNAs, lead to an additional hypothesis that is proposed here.
细胞毒性药物 5-氟尿嘧啶（5-FU）的主要分子作用模式通常被认为是由于胸苷酸合成酶抑制所致。最近与人类尿嘧啶-5-甲基转移酶（U5MT）、TRMT2A 的功能及其与 tRNA 内掺入的 5-FU 代谢物相互作用相关的发现，导致了这里提出的另一个假设。
