College of Pharmaceutical Science, Zhejiang University of Technology, Hangzhou, 310032, China.
J Ethnopharmacol. 2020 Aug 10;258:112912. doi: 10.1016/j.jep.2020.112912. Epub 2020 Apr 26.
Dipsacus asper Wall. ex C.B. Clarke, a traditional Chinese herbal medicine, has long been used in China for the therapy of bone diseases (e.g. bone fracture, osteoporosis, rheumatic arthritis), traumatic hematoma, uterine bleeding and those caused by the deficiency of liver and kidney.
This work aims to evaluate current research progress on chemical constituents, pharmacological activities, quality control, and pharmacokinetic of Dipsacus asper Wall. ex C.B. Clarke, pinpoint the shortcomings of existing studies, and provide meaningful guidelines for our future investigations.
Extensive database retrieval, such as PubMed, SciFinder and CNKI, was carried out by using keywords such as "Dipsacus asper", "Radix Dipsaci", and "Xuduan". Furthermore, relevant textbooks, patents, reviews, and digital documents were consulted to collate all available scientific literature and to provide a complete science-based survey of the topic.
More than 100 compounds have been isolated and identified from Dipsacus asper Wall. ex C.B. Clarke, a substantial proportion of which were reported to be triterpenoids and iridoids. Biological effects such as protective effects against bone fracture, anti-osteoporosis, neuroprotective, cardioprotective, anti-aging and protection of reproductive system activities were also evaluated in vitro and in vivo.
Diaphoretic processing resulted in the drop in the content of asperosaponin VI, which was highly associated with bone protective effect of DA. Therefore, diaphoretic processing was not a suitable processing method for DA. Although Dipsacus asper Wall. ex C.B. Clarke was traditionally used for therapy of osteoarthritis, the in-depth study of the underlying mechanism was very rare. Much endeavor had been made on the effect of DA on bone fracture. Notably, high-dose of Dipsacus asper administration may cause adverse impacts in maternal healthy and embryo-fetal development. It's not suitable for further development in those bioactivities, such as anti-inflammatory and free radical scavenging, which are shared in many other plant species. Pharmacological effects of individual component of DA is not equivalent to its traditional usage. Attention should be paid to the traditional effect of extract of DA.
川续断，一种传统的中药，在中国长期以来一直用于治疗骨病（如骨折、骨质疏松、风湿性关节炎）、外伤性血肿、子宫出血和肝肾不足引起的疾病。
本研究旨在评估川续断的化学成分、药理活性、质量控制和药代动力学的研究进展，指出现有研究的不足，并为我们未来的研究提供有意义的指导。
通过使用“川续断”、“续断”等关键词，在 PubMed、SciFinder 和 CNKI 等数据库中进行了广泛的检索。此外，还查阅了相关教材、专利、综述和数字文献，对所有可用的科学文献进行了整理，为该主题提供了一个完整的基于科学的调查。
从川续断中分离鉴定出 100 多种化合物，其中大部分为三萜类和环烯醚萜类化合物。还在体外和体内评价了其生物效应，如对骨折的保护作用、抗骨质疏松作用、神经保护作用、心脏保护作用、抗衰老作用和生殖系统保护作用。
发汗处理导致续断皂苷 VI 的含量下降，这与 DA 的骨保护作用高度相关。因此，发汗处理不是 DA 的合适处理方法。虽然川续断传统上用于治疗骨关节炎，但对其潜在机制的深入研究却很少。川续断对骨折的作用研究取得了很大进展。值得注意的是，大剂量川续断可能会对母体健康和胚胎-胎儿发育产生不良影响。在抗炎、清除自由基等许多其他植物物种共有的生物活性方面，不适合进一步开发。DA 的单个成分的药理作用不等同于其传统用途。应注意川续断提取物的传统作用。
