Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan,
Department of Pharmaceutical Sciences, Suzuka University of Medical Science, Suzuka, Japan.
Pharmacology. 2020;105(11-12):652-661. doi: 10.1159/000506233. Epub 2020 Apr 29.
In a rapidly aging society, the number of people suffering from osteoporosis keeps increasing. However, effective prevention strategies for osteoporosis are not yet currently available.
In this study, we examined the ameliorative effects of tranexamic acid on osteoporosis in 24-month-old mice.
During the study period, mice were orally administered tranexamic acid 3 times per week.
Bone mineral density, which is a parameter of osteoporosis, was improved following tranexamic acid administration. In addition, female mice evidenced a stronger phenotypic improvement than male mice. In female mice treated with tranexamic acid, ovary abnormalities were reduced. Furthermore, the levels of transforming growth factor-β, hyaluronic acid, CD44, reactive oxygen species, and apoptosis, as well as the number of infiltrated neutrophils and macrophages in the ovary were lower than those in the control or solvent-administered mice. In addition, 17β-estradiol levels in blood increased when compared with the control or solvent-treated mice. In addition, administration of tranexamic acid to 24-month-old male mice decreased the level of apoptosis in the testis. However, the levels of 17β-estradiol and testosterone in blood increased compared with the control or solvent-administered mice.
The use of tranexamic acid had an ameliorative effect on osteoporosis, possibly by protecting ovaries and testes.
在快速老龄化的社会中，骨质疏松症患者的数量不断增加。然而，目前还没有有效的骨质疏松症预防策略。
在本研究中，我们研究了氨甲环酸对 24 月龄小鼠骨质疏松症的改善作用。
在研究期间，每周给小鼠口服氨甲环酸 3 次。
骨矿物质密度（骨质疏松症的一个参数）在氨甲环酸给药后得到改善。此外，雌性小鼠的表型改善比雄性小鼠更强。在接受氨甲环酸治疗的雌性小鼠中，卵巢异常减少。此外，卵巢中转化生长因子-β、透明质酸、CD44、活性氧和细胞凋亡的水平以及浸润的中性粒细胞和巨噬细胞的数量低于对照组或溶剂处理组。此外，与对照组或溶剂处理组相比，血液中的 17β-雌二醇水平增加。此外，给 24 月龄雄性小鼠给予氨甲环酸可降低睾丸细胞凋亡水平。然而，与对照组或溶剂处理组相比，血液中的 17β-雌二醇和睾酮水平增加。
氨甲环酸对骨质疏松症有改善作用，可能通过保护卵巢和睾丸。
