Department of Pharmaceutical Sciences, Suzuka University of Medical Science, 3500-3, Minamitamagakicho, Suzuka, Mie, 513-8670, Japan.
R&D Department, Daiichi Sankyo Healthcare Co., Ltd., Chuo-ku, Tokyo, Japan.
Inflammopharmacology. 2019 Dec;27(6):1319-1323. doi: 10.1007/s10787-019-00616-2. Epub 2019 Jun 24.
An effective method to improve lifespan is not known. Therefore, in this study, we examined the lifespan-extending effect of tranexamic acid in normal mice. We bred hairless mice without exposure to ultraviolet radiation and psychical stress until they died naturally. During the study period, the mice were orally administered tranexamic acid (12 mg/kg/day) three times weekly. An increase in the lifespan of mice was observed by tranexamic acid administration. Furthermore, age-related diseases of the skin were ameliorated by tranexamic acid administration. Moreover, the blood level of tumor necrosis factor-α, interleukin-6, reactive oxygen species (ROS), and matrix metalloproteinase (MMP)-9 was decreased by tranexamic acid administration. These results indicate that tranexamic acid suppresses the secretion of inflammatory cytokines, MMP-9, and ROS induced by natural aging, ameliorating age-related diseases, and, consequently, extending the lifespan.
目前尚未发现能够有效延长寿命的方法。因此，在本研究中，我们检验了氨甲环酸对正常小鼠寿命的延长作用。我们繁育无毛小鼠，使其不接受紫外线辐射和精神压力，直至其自然死亡。在研究期间，每周三次通过口服给予小鼠氨甲环酸（12mg/kg/天）。我们观察到氨甲环酸给药可使小鼠的寿命延长。此外，氨甲环酸给药可改善与年龄相关的皮肤疾病。此外，氨甲环酸给药可降低肿瘤坏死因子-α、白细胞介素-6、活性氧（ROS）和基质金属蛋白酶（MMP）-9 的血液水平。这些结果表明，氨甲环酸可抑制自然衰老诱导的炎症细胞因子、MMP-9 和 ROS 的分泌，改善与年龄相关的疾病，从而延长寿命。
