Ocular Oncology Service, Wills Eye Hospital, Thomas Jefferson University, Philadelphia, Pennsylvania.
Department of Ophthalmology, Shanghai General Hospital, Shanghai, China; and.
Retina. 2021 Feb 1;41(2):249-258. doi: 10.1097/IAE.0000000000002819.
To evaluate spectral domain optical coherence tomography (SD-OCT) features of vitreoretinal lymphoma (VRL).
Review of records and SD-OCT images of vitreoretinal lymphoma evaluated at Ocular Oncology Service, Wills Eye Hospital between July 1, 2000, and April 1, 2019.
There were 55 eyes of 32 patients included. At presentation, SD-OCT features included vitreous opacities (n = 36, 65%), preretinal deposits (n = 7, 13%), intraretinal deposits (n = 8, 15%), subretinal deposits (n = 20, 36%), retinal pigment epithelium abnormalities (n = 35, 64%), and subretinal pigment epithelium deposits (n = 35, 64%). Of 36 eyes with observed tumor progression, comparison (initial visit vs. time of progression) revealed more intraretinal deposits (17% vs. 50%, P = 0.005) at progression. Of 15 eyes with tumor recurrence, comparison (initial visit vs. time of recurrence) revealed more intraretinal deposits (7% vs. 47%, P = 0.04) at recurrence. At last visit, 39 eyes demonstrated tumor regression. By comparison (initial presentation vs. regression), there were less frequent vitreous opacities (67% vs. 0%, P < 0.001), intraretinal deposits (15% vs. 0%, P = 0.03), subretinal deposits (36% vs. 0%, P < 0.001), and subretinal pigment epithelium deposits (69% vs. 21%, P < 0.001) at regression.
Using SD-OCT in patients with vitreoretinal lymphoma, local tumor regression correlated with a reduction in vitreous opacities, intraretinal deposits, subretinal deposits, and subretinal pigment epithelium deposits. SD-OCT is useful in judging vitreoretinal lymphoma response to therapy.
评估玻璃体内视网膜淋巴瘤（VRL）的光谱域光相干断层扫描（SD-OCT）特征。
回顾 2000 年 7 月 1 日至 2019 年 4 月 1 日期间在 Wills 眼科医院眼肿瘤科评估的玻璃体内视网膜淋巴瘤的病历记录和 SD-OCT 图像。
共纳入 32 名患者的 55 只眼。在发病时，SD-OCT 特征包括玻璃体混浊（n=36，65%）、视网膜前沉积（n=7，13%）、视网膜内沉积（n=8，15%）、视网膜下沉积（n=20，36%）、视网膜色素上皮异常（n=35，64%）和视网膜下色素上皮沉积（n=35，64%）。在观察到肿瘤进展的 36 只眼中，比较（初次就诊与进展时）显示进展时更多的视网膜内沉积（17%对 50%，P=0.005）。在 15 只肿瘤复发的眼中，比较（初次就诊与复发时）显示复发时更多的视网膜内沉积（7%对 47%，P=0.04）。在最后一次就诊时，39 只眼显示肿瘤消退。通过比较（初次就诊与消退），玻璃体混浊的频率更低（67%对 0%，P<0.001），视网膜内沉积（15%对 0%，P=0.03），视网膜下沉积（36%对 0%，P<0.001）和视网膜下色素上皮沉积（69%对 21%，P<0.001）。
在玻璃体内视网膜淋巴瘤患者中使用 SD-OCT，局部肿瘤消退与玻璃体混浊、视网膜内沉积、视网膜下沉积和视网膜下色素上皮沉积的减少相关。SD-OCT 有助于判断玻璃体内视网膜淋巴瘤对治疗的反应。
