Wagner Robert, Fritsche Andreas
Dtsch Med Wochenschr. 2020 May;145(9):601-608. doi: 10.1055/a-0983-0349. Epub 2020 Apr 29.
Diabetes mellitus has been defined by hyperglycemia, but in addition to hyperglycemia, there are several other factors determining the clinical course and complications. We review the current classification of diabetes and recent attempts to identify new subphenotypes. Notably, there are anthropometry-pathophysiology based and genome-based subphenotyping approaches. They aim to improve the prediction of disease course and complications and could pave the way for precision medicine in the therapy of diabetes.
糖尿病已被定义为高血糖，但除高血糖外，还有其他几个因素决定临床病程和并发症。我们综述了糖尿病的当前分类以及最近识别新亚表型的尝试。值得注意的是，有基于人体测量学 - 病理生理学和基于基因组的亚表型分析方法。它们旨在改善对疾病病程和并发症的预测，并可能为糖尿病治疗中的精准医学铺平道路。
