Institute for Diabetes Research and Metabolic Diseases of the Helmholtz Center Munich at the University of Tübingen, Tübingen, Germany.
German Center for Diabetes Research (DZD), Tübingen, Germany.
Nat Rev Endocrinol. 2022 Jan;18(1):43-54. doi: 10.1038/s41574-021-00573-3. Epub 2021 Oct 20.
Fat accumulation outside subcutaneous adipose tissue often has unfavourable effects on systemic metabolism. In addition to non-alcoholic fatty liver disease, which has received considerable attention, pancreatic fat has become an important area of research throughout the past 10 years. While a number of diagnostic approaches are available to quantify pancreatic fat, multi-echo Dixon MRI is currently the most developed method. Initial studies have shown associations between pancreatic fat and the metabolic syndrome, impaired glucose metabolism and type 2 diabetes mellitus. Pancreatic fat is linked to reduced insulin secretion, at least under specific circumstances such as prediabetes, low BMI and increased genetic risk of type 2 diabetes mellitus. This Review summarizes the possible causes and metabolic consequences of pancreatic fat accumulation. In addition, potential therapeutic approaches for addressing pancreatic fat accumulation are discussed.
脂肪在皮下脂肪组织以外的堆积常常对全身代谢产生不良影响。除了受到广泛关注的非酒精性脂肪肝外，胰腺脂肪在过去 10 年已成为一个重要的研究领域。虽然有多种方法可用于定量检测胰腺脂肪，但多回波 Dixon MRI 目前是最成熟的方法。初步研究表明，胰腺脂肪与代谢综合征、葡萄糖代谢受损和 2 型糖尿病之间存在关联。胰腺脂肪与胰岛素分泌减少有关，至少在某些情况下如此，如糖尿病前期、低 BMI 和 2 型糖尿病的遗传风险增加。本综述总结了胰腺脂肪堆积的可能原因和代谢后果。此外，还讨论了针对胰腺脂肪堆积的潜在治疗方法。
