Department of Neurosurgery and Pediatric Neurosurgery, Medical University of Lublin, Jaczewskiego 8, 20-954 Lublin, Poland.
Department of Anatomy, Medical University of Lublin, Jaczewskiego 4, 20-090 Lublin, Poland.
Int J Mol Sci. 2020 Apr 27;21(9):3046. doi: 10.3390/ijms21093046.
Central nervous system tumors are a significant problem for modern medicine because of their location. The explanation of the importance of microRNA (miRNA) in the development of cancerous changes plays an important role in this respect. The first papers describing the presence of miRNA were published in the 1990s. The role of miRNA has been pointed out in many medical conditions such as kidney disease, diabetes, neurodegenerative disorder, arthritis and cancer. There are several miRNAs responsible for invasiveness, apoptosis, resistance to treatment, angiogenesis, proliferation and immunology, and many others. The research conducted in recent years analyzing this group of tumors has shown the important role of miRNA in the course of gliomagenesis. These particles seem to participate in many stages of the development of cancer processes, such as proliferation, angiogenesis, regulation of apoptosis or cell resistance to cytostatics.
中枢神经系统肿瘤因其位置而成为现代医学的一个重大问题。在这方面，microRNA（miRNA）在癌症变化发展中的重要性的解释起着重要作用。描述 miRNA 存在的第一篇论文发表于 20 世纪 90 年代。miRNA 的作用已在许多医学病症中被指出，如肾脏疾病、糖尿病、神经退行性疾病、关节炎和癌症。有几种 miRNA 负责侵袭、凋亡、对治疗的抵抗、血管生成、增殖和免疫学等。近年来对这些肿瘤进行的研究表明 miRNA 在神经胶质瘤发生过程中起着重要作用。这些粒子似乎参与了癌症过程发展的许多阶段，如增殖、血管生成、凋亡调控或细胞对细胞抑制剂的耐药性。
