Headache and Craniofacial Pain Unit, Neurology Department, Hospital Universitari Vall d'Hebron, Headache and Neurological Pain Research Group, Vall d'Hebron Research Institute (VHIR), Departament de Medicina, Universitat Autònoma de Barcelona, Barcelona, Spain.
Headache Center, Child Neurology Unit, Bambino Gesu' Children's Hospital, Rome, Italy.
J Headache Pain. 2020 Apr 29;21(1):42. doi: 10.1186/s10194-020-01111-8.
Chronic migraine is a neurological disorder characterized by 15 or more headache days per month of which at least 8 days show typical migraine features. The process that describes the development from episodic migraine into chronic migraine is commonly referred to as migraine transformation or chronification. Ample studies have attempted to identify factors associated with migraine transformation from different perspectives. Understanding CM as a pathological brain state with trigeminovascular participation where biological changes occur, we have completed a comprehensive review on the clinical, epidemiological, genetic, molecular, structural, functional, physiological and preclinical evidence available.
慢性偏头痛是一种神经系统疾病，其特征为每月头痛发作 15 天或以上，其中至少 8 天具有典型偏头痛特征。描述从阵发性偏头痛发展为慢性偏头痛的过程通常称为偏头痛转化或慢性化。大量研究试图从不同角度确定与偏头痛转化相关的因素。我们将 CM 理解为一种具有三叉血管参与的病理性脑状态，其中会发生生物学变化，因此完成了对现有临床、流行病学、遗传、分子、结构、功能、生理和临床前证据的全面综述。
