Migraine is a genetically influenced complex neurological disease characterized by attacks of moderate to severe headaches and a variety of concomitant symptoms. Migraine disease can significantly impact individuals' daily activities and quality of life. It is a major cause of disability and loss of productivity, which can be exacerbated by migraine-related stigma. Recent advances in migraine treatment and ongoing research may offer additional options for patients; however, treatment barriers still exist, resulting in underdiagnosis and undertreatment of migraine disease, especially in some minority and vulnerable groups. Primary care and emergency department providers are often the first point of contact for patients with migraine disease, so there is opportunity for them to assist in addressing these barriers, particularly with strategies to make care more patient-centered. Managed care organizations can also play a role in overcoming these barriers and supporting equitable access.