California Poison Control System, 200 W. Arbor Drive, San Diego, CA 92103, USA.
Am J Emerg Med. 2020 Jul;38(7):1545.e1-1545.e2. doi: 10.1016/j.ajem.2020.04.039. Epub 2020 Apr 17.
There is no pediatric overdose information available for perampanel. We present twocases involving children 2 years of age. A female ingested 0.77mg/kg perampanel anddeveloped drowsiness and ataxia within an hour, followed by bradycardia after 6 hours.She was admitted to the pediatric intensive care unit and given fluids and was thendischarged after 20 hours. The other case involved a male who ingested 0.25mg/kgperampanel and developed ataxia within an hour, eventually he was discharged after 6hour observation in the emergency department without any treatment.
尚无关于吡仑帕奈儿童用药过量的信息。我们报告了两例涉及 2 岁儿童的病例。一名女性摄入了 0.77mg/kg 的吡仑帕奈,在 1 小时内出现了嗜睡和共济失调,6 小时后出现了心动过缓。她被收入儿科重症监护病房,并给予补液治疗,20 小时后出院。另一个病例涉及一名男性,摄入了 0.25mg/kg 的吡仑帕奈,在 1 小时内出现了共济失调,最终他在急诊科观察 6 小时后没有接受任何治疗就出院了。