• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利：CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法，用中文像聊天一样搜索，搜遍4000万医学文献。AI智能推荐，让科研检索更轻松。

立即免费搜索

文件翻译

保留排版，准确专业，支持PDF/Word/PPT等文件格式，支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述，25分钟生成高质量综述，智能提取关键信息，辅助科研写作。

立即免费体验

Perampanel monotherapy in pediatric epilepsy: Emphasizing the need for comprehensive safety evaluation.

作者信息

de Farias Morais Gabriel Christian, Alves Guilherme Bastos, Akter Shahina, Akash Shopnil, Aktaruzzaman Md, Al Hasan Md Sakib, Fulco Umberto Laino, da Silva Junior Edilson Dantas, Oliveira Jonas Ivan Nobre

机构信息

Department of Biophysics and Pharmacology, Bioscience Center, Federal University of Rio Grande do Norte, Natal, Brazil.

Bangladesh Council of Scientific and Industrial Research (BCSIR), Dhaka, Bangladesh.

出版信息

Epilepsia Open. 2025 Jun;10(3):971-975. doi: 10.1002/epi4.70031. Epub 2025 Apr 8.

DOI:10.1002/epi4.70031
PMID:40197864
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC12163510/
Abstract
摘要
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd06/12163510/860a50a06140/EPI4-10-971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd06/12163510/860a50a06140/EPI4-10-971-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/cd06/12163510/860a50a06140/EPI4-10-971-g001.jpg

相似文献

1
Perampanel monotherapy in pediatric epilepsy: Emphasizing the need for comprehensive safety evaluation.吡仑帕奈单药治疗小儿癫痫：强调全面安全性评估的必要性。
Epilepsia Open. 2025 Jun;10(3):971-975. doi: 10.1002/epi4.70031. Epub 2025 Apr 8.
2
A non-inferiority randomized controlled study of Perampanel versus Oxcarbazepine monotherapy for post-stroke epilepsy.吡仑帕奈与奥卡西平单药治疗卒中后癫痫的非劣效性随机对照研究。
Seizure. 2025 Feb;125:172-178. doi: 10.1016/j.seizure.2025.01.016. Epub 2025 Jan 11.
3
Efficacy of perampanel by etiology in Japanese patients with epilepsy-subpopulation analysis of a prospective post-marketing observational study.依病因分层的日本癫痫患者中吡仑帕奈的疗效：一项前瞻性上市后观察性研究的亚人群分析。
Epilepsia Open. 2024 Oct;9(5):1772-1782. doi: 10.1002/epi4.13002. Epub 2024 Jul 4.
4
Investigation of efficacy, safety and tolerability of perampanel monotherapy in children with newly-diagnosed epilepsy in routine clinical practice in China: a multicenter prospective observational study.在中国常规临床实践中，吡仑帕奈单药治疗新诊断癫痫儿童的疗效、安全性及耐受性研究：一项多中心前瞻性观察性研究
World J Pediatr. 2025 May 27. doi: 10.1007/s12519-025-00914-6.
5
Long-term efficacy and safety of perampanel monotherapy in patients with newly diagnosed or currently untreated recurrent focal-onset seizures: Results from the open-label extension phase of FREEDOM (Study 342).吡仑帕奈单药治疗新诊断或当前未治疗的局灶性发作性癫痫患者的长期疗效和安全性：FREEDOM开放标签延长期（研究342）的结果
Epilepsy Res. 2025 Feb;210:107494. doi: 10.1016/j.eplepsyres.2024.107494. Epub 2024 Dec 20.
6
Effectiveness of perampanel as the only adjunctive anti-seizure medication in adults: Final results from the observational PERPRISE study in Germany.吡仑帕奈作为成人唯一辅助抗癫痫药物的有效性：德国观察性PERPRISE研究的最终结果。
Epilepsia Open. 2025 Aug 21. doi: 10.1002/epi4.70117.
7
Perampanel as first line monotherapy for seizure in japan. A single-centre real-world study.吡仑帕奈作为日本癫痫一线单药治疗：一项单中心真实世界研究
Acta Neurol Belg. 2025 Aug 18. doi: 10.1007/s13760-025-02865-1.
8
Real-world use of adjunctive perampanel for focal-onset seizures in Italy: A mirroring clinical practice study of perampanel in adults and adolescents (AMPA).在意大利辅助使用吡仑帕奈治疗局灶性发作的真实世界应用：吡仑帕奈在成人和青少年中的镜像临床实践研究（AMPA）
Epilepsia Open. 2025 Jun 4. doi: 10.1002/epi4.70068.
9
Perampanel add-on for drug-resistant focal epilepsy.添加氨己烯酸治疗耐药性局灶性癫痫。
Cochrane Database Syst Rev. 2023 Apr 14;4(4):CD010961. doi: 10.1002/14651858.CD010961.pub2.
10
Time to prerandomization seizure count design sufficiently assessed the safety and tolerability of perampanel for the treatment of primary generalized tonic-clonic seizures.随机分组前癫痫发作次数的评估充分考察了吡仑帕奈治疗原发性全面强直-阵挛发作的安全性和耐受性。
Epilepsia. 2024 Aug;65(8):2412-2422. doi: 10.1111/epi.18023. Epub 2024 Jun 12.

本文引用的文献

1
Discovery of Galangin Derivatives as a Potential T-cell Leukemia Virus 1 Protease Inhibitor Through Chemoinformatics Approaches.通过化学信息学方法发现高良姜素衍生物作为潜在的1型T细胞白血病病毒蛋白酶抑制剂
Cell Biochem Biophys. 2025 Jun;83(2):2067-2088. doi: 10.1007/s12013-024-01618-w. Epub 2024 Dec 3.
2
Clinical efficacy and safety of perampanel monotherapy as primary anti-seizure medication in the treatment of pediatric epilepsy: A single-center, prospective, observational study.吡仑帕奈单药治疗作为小儿癫痫主要抗癫痫药物的临床疗效和安全性：一项单中心、前瞻性、观察性研究。
Epilepsia Open. 2024 Dec;9(6):2209-2218. doi: 10.1002/epi4.13043. Epub 2024 Sep 18.
3
Tolerability of perampanel: A retrospective study at the department of psychiatry.
佩南朋的耐受性：精神科的回顾性研究。
Epilepsy Behav. 2024 Jul;156:109797. doi: 10.1016/j.yebeh.2024.109797. Epub 2024 May 23.
4
Perampanel for the treatment of epilepsy with genetic aetiology: Real-world evidence from the PERMIT Extension study.基因病因性癫痫的治疗用吡仑帕奈：PERMIT 扩展研究的真实世界证据。
Epilepsy Res. 2024 May;202:107339. doi: 10.1016/j.eplepsyres.2024.107339. Epub 2024 Mar 2.
5
Efficacy and Tolerability of Perampanel in Brain Tumor-Related Epilepsy: A Systematic Review.吡仑帕奈治疗脑肿瘤相关性癫痫的疗效与耐受性：一项系统评价
Biomedicines. 2023 Feb 21;11(3):651. doi: 10.3390/biomedicines11030651.
6
A Case of Perampanel Overdose Presenting with Respiratory Failure.一例以呼吸衰竭为表现的吡仑帕奈过量病例。
J Epilepsy Res. 2022 Dec 30;12(2):68-70. doi: 10.14581/jer.22012. eCollection 2022 Dec.
7
Efficacy and adverse reactions of perampanel in the treatment of epilepsy in children.吡仑帕奈治疗儿童癫痫的疗效与不良反应
Front Neurol. 2022 Jul 27;13:924057. doi: 10.3389/fneur.2022.924057. eCollection 2022.
8
Perampanel enhances the cardiovagal tone and heart rate variability (HRV) in patients with drug-resistant temporal lobe epilepsy.吡仑帕奈可增强耐药性颞叶癫痫患者的心交感神经张力和心率变异性（HRV）。
Seizure. 2022 Jul;99:16-23. doi: 10.1016/j.seizure.2022.04.013. Epub 2022 Apr 29.
9
ADMETlab 2.0: an integrated online platform for accurate and comprehensive predictions of ADMET properties.ADMETlab 2.0：一个集成的在线平台，用于准确全面地预测 ADMET 性质。
Nucleic Acids Res. 2021 Jul 2;49(W1):W5-W14. doi: 10.1093/nar/gkab255.
10
Pediatric perampanel poisoning.儿童吡仑帕奈中毒。
Am J Emerg Med. 2020 Jul;38(7):1545.e1-1545.e2. doi: 10.1016/j.ajem.2020.04.039. Epub 2020 Apr 17.