Hansen Erik Soeren Halvard, Pitzner-Fabricius Anders, Toennesen Louise Lindhardt, Rasmusen Hanne Kruuse, Hostrup Morten, Hellsten Ylva, Backer Vibeke, Henriksen Marius
Centre for Physical Activity Research (CFAS), Rigshospitalet, Copenhagen, Denmark
Centre for Physical Activity Research (CFAS), Rigshospitalet, Copenhagen, Denmark.
Eur Respir J. 2020 Jul 30;56(1). doi: 10.1183/13993003.00146-2020. Print 2020 Jul.
To evaluate the effect of aerobic exercise training on asthma control, lung function and airway inflammation in adults with asthma.
Systematic review and meta-analysis.
Randomised controlled trials investigating the effect of ≥8 weeks of aerobic exercise training on outcomes for asthma control, lung function and airway inflammation in adults with asthma were eligible for study. MEDLINE, Embase, CINAHL, PEDro and the Cochrane Central Register of Controlled Trials (CENTRAL) were searched up to April 3, 2019. Risk of bias was assessed using the Cochrane Risk of Bias Tool.
We included 11 studies with a total of 543 adults with asthma. Participants' mean (range) age was 36.5 (22-54) years; 74.8% of participants were female and the mean (range) body mass index was 27.6 (23.2-38.1) kg·m. Interventions had a median (range) duration of 12 (8-12) weeks and included walking, jogging, spinning, treadmill running and other unspecified exercise training programmes. Exercise training improved asthma control with a standard mean difference (SMD) of -0.48 (-0.81--0.16). Lung function slightly increased with an SMD of -0.36 (-0.72-0.00) in favour of exercise training. Exercise training had no apparent effect on markers of airway inflammation (SMD -0.03 (-0.41-0.36)).
In adults with asthma, aerobic exercise training has potential to improve asthma control and lung function, but not airway inflammation.
评估有氧运动训练对成年哮喘患者哮喘控制、肺功能及气道炎症的影响。
系统评价与荟萃分析。
纳入研究≥8周有氧运动训练对成年哮喘患者哮喘控制、肺功能及气道炎症影响的随机对照试验。检索MEDLINE、Embase、CINAHL、PEDro及Cochrane对照试验中心注册库（CENTRAL）至2019年4月3日。使用Cochrane偏倚风险工具评估偏倚风险。
我们纳入了11项研究，共543例成年哮喘患者。参与者的平均（范围）年龄为36.5（22 - 54）岁；74.8%的参与者为女性，平均（范围）体重指数为27.6（23.2 - 38.1）kg·m²。干预的中位（范围）持续时间为12（8 - 12）周，包括步行、慢跑、动感单车、跑步机跑步及其他未明确的运动训练项目。运动训练改善了哮喘控制，标准平均差（SMD）为 -0.48（-0.81 - -0.16）。肺功能略有增加，支持运动训练的SMD为 -0.36（-0.72 - 0.00）。运动训练对气道炎症标志物无明显影响（SMD -0.03（-0.41 - 0.36））。
在成年哮喘患者中，有氧运动训练有改善哮喘控制和肺功能的潜力，但对气道炎症无作用。
