Department of Neurosurgery - Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Faculty of Medicine, Jordan University of Science and Technology, Irbid, Jordan.
Am J Case Rep. 2020 Apr 30;21:e922312. doi: 10.12659/AJCR.922312.
BACKGROUND Incomplete closure of the neural tube results in congenital anomalies called neural tube defects (NTD). These defects are rarely multiple, and are characterized by loss of central nervous system soft tissue and bony coverings, along with herniation of the involved part of the CNS through the defect. CASE REPORT A newborn female infant was delivered through planned cesarean section due to large occipital encephalocele diagnosed antenatally. The pregnancy was unplanned and the mother did not take folic acid prior to conception. Birth weight was 3.41 Kg. Upon delivery, the newborn was healthy, with an Apgar score of 8. The physical examination revealed 2 large pouches; one was over the occiput, and the other swelling was located over the nape of the neck. Brain MRI revealed large occipital encephalocele and cervical myelomeningocele. The 2 defects were repaired separately, with an uneventful postoperative course. CONCLUSIONS We report the rare occurrence of multiple NTD. Early repair, either as single or multiple procedures, is mandatory to avoid dramatic complications.
神经管未完全闭合会导致神经管缺陷（NTD）等先天性畸形。这些缺陷很少是多发性的，其特征是中枢神经系统软组织和骨覆盖物缺失，并伴有 CNS 受累部分通过缺陷疝出。
一名新生女婴因产前诊断出巨大枕骨脑膨出而通过计划剖宫产分娩。该妊娠为非计划妊娠，母亲在受孕前未服用叶酸。出生体重为 3.41kg。分娩时，新生儿健康，阿普加评分为 8 分。体格检查显示有 2 个大的囊袋；一个位于枕骨，另一个肿胀位于颈背。脑 MRI 显示巨大枕骨脑膨出和颈髓脊膜膨出。这 2 个缺陷分别进行了修复，术后过程顺利。
我们报告了罕见的多发性 NTD 病例。早期修复，无论是单一或多个手术，都是必需的，以避免严重的并发症。
