小鼠异物肿瘤：潜伏期和发病率的品系及性别差异。

Foreign-body tumors of mice: strain and sex differences in latency and incidence.

作者信息

Brand I, Buoen L C, Brand K G

出版信息

J Natl Cancer Inst. 1977 May;58(5):1443-7. doi: 10.1093/jnci/58.5.1443.

DOI:10.1093/jnci/58.5.1443

Abstract

Sarcomas were induced by sc implantation of unplasticized polyvinylchloride acetate films in female and male mice of strains AKR/J, BALB/cJ, BALB/cWat, CBA/H and CBA/H-T6, C3H/HeJ, C57BL/10ScSn, C57BL/6J-bgj, C57BL/cdJ, DBA/-1J l/LnJ, LP/J, SJL/J, X/Gf, 129/J, and hybrids (CBA/H-T6 X AKR/J)F1, (C57BL/10ScSn x CBA/H or CBA/H-T6)F1, (C57BL/6J-bgj x C57BL/6J)F1. The strains and sexes showed marked differences in incidence and mean latency of resulting tumors. Crucial information was provided for the selection of appropriate mouse strains for the study of interrelationships between genotypes, defined somatic properties, and the multifactorial process of foreign-body tumorigenesis.

摘要

通过将未增塑的聚氯乙烯醋酸酯薄膜皮下植入AKR/J、BALB/cJ、BALB/cWat、CBA/H和CBA/H-T6、C3H/HeJ、C57BL/10ScSn、C57BL/6J-bgj、C57BL/cdJ、DBA/-1J l/LnJ、LP/J、SJL/J、X/Gf、129/J等品系以及杂交品系（CBA/H-T6×AKR/J）F1、（C57BL/10ScSn×CBA/H或CBA/H-T6）F1、（C57BL/6J-bgj×C57BL/6J）F1的雌性和雄性小鼠体内诱导肉瘤形成。这些品系和性别在所得肿瘤的发生率和平均潜伏期方面表现出显著差异。为选择合适的小鼠品系以研究基因型、特定体细胞特性和异物致瘤多因素过程之间的相互关系提供了关键信息。