Institute of Hematology Research, the First Affiliated Hospital of Zhejiang Chinese Medical University, Hangzhou, 310006, China.
Chin J Integr Med. 2020 May;26(5):324-329. doi: 10.1007/s11655-020-3252-y. Epub 2020 Apr 29.
Graft-versus-host disease (GVHD) is the most common complication after allogeneic hematopoietic stem cell transplantation, and also an important factor affecting the survival and quality of life in patients after transplantation. Currently, immunosuppressive therapy is commonly used for GVHD, but the curative effect is not ideal. How to effectively prevent and treat GVHD is one of the difficulties to be solved urgently in the field of transplantation. In this paper, we summarize the latest progress in pathogenesis, prevention and treatment of GVHD with Chinese medicine (CM). We hope it will provide ideas and methods for exploring the mechanism and establishing a new comprehensive therapy for GVHD with CM.
移植物抗宿主病（GVHD）是异基因造血干细胞移植后最常见的并发症，也是影响移植后患者生存和生活质量的重要因素。目前，GVHD 常采用免疫抑制治疗，但疗效并不理想。如何有效预防和治疗 GVHD 是移植领域亟待解决的难点之一。本文就中药防治 GVHD 的发病机制、防治方法的最新研究进展进行综述，以期为进一步探索中药防治 GVHD 的作用机制和建立新的综合治疗方法提供思路和方法。
