• 文献检索
  • 文档翻译
  • 深度研究
  • 学术资讯
  • Suppr Zotero 插件Zotero 插件
  • 邀请有礼
  • 套餐&价格
  • 历史记录
应用&插件
Suppr Zotero 插件Zotero 插件浏览器插件Mac 客户端Windows 客户端微信小程序
定价
高级版会员购买积分包购买API积分包
服务
文献检索文档翻译深度研究API 文档MCP 服务
关于我们
关于 Suppr公司介绍联系我们用户协议隐私条款
关注我们

Suppr 超能文献

核心技术专利:CN118964589B侵权必究
粤ICP备2023148730 号-1Suppr @ 2026

文献检索

告别复杂PubMed语法,用中文像聊天一样搜索,搜遍4000万医学文献。AI智能推荐,让科研检索更轻松。

立即免费搜索

文件翻译

保留排版,准确专业,支持PDF/Word/PPT等文件格式,支持 12+语言互译。

免费翻译文档

深度研究

AI帮你快速写综述,25分钟生成高质量综述,智能提取关键信息,辅助科研写作。

立即免费体验

《造血干细胞移植后急性移植物抗宿主病诊断与治疗中国专家共识(2024年版)》

[Chinese expert consensus on the diagnosis and treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation (2024)].

出版信息

Zhonghua Xue Ye Xue Za Zhi. 2024 Jun 14;45(6):525-533. doi: 10.3760/cma.j.cn121090-20240608-00214.

DOI:10.3760/cma.j.cn121090-20240608-00214
PMID:39134482
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC11310805/
Abstract

Despite the continuous improvement in the efficacy of allogeneic hematopoietic stem cell transplantation (allo-HSCT), acute graft-versus-host disease (GVHD) remains a major complication and cause of death. In recent years, with the emergence of new drugs for the prevention and treatment of acute GVHD and the update of a series of clinical studies, there have been varying degrees of changes in the routine prevention and treatment regimens for acute GVHD. Based on the main research achievements and the accumulation of clinical experience in this field in recent years, this consensus further updates the "The Consensus on Allogeneic Hematopoietic Stem Cell Transplantation for Hematological Diseases in China-Acute Graft-Versus-Host Disease (2020) .

摘要

尽管异基因造血干细胞移植(allo-HSCT)的疗效不断提高,但急性移植物抗宿主病(GVHD)仍然是主要并发症和死亡原因。近年来,随着急性GVHD防治新药的出现以及一系列临床研究的更新,急性GVHD的常规防治方案发生了不同程度的变化。基于该领域近年来的主要研究成果和临床经验积累,本共识进一步更新了《中国血液系统疾病异基因造血干细胞移植——急性移植物抗宿主病(2020年版)》。

相似文献

1
[Chinese expert consensus on the diagnosis and treatment of acute graft-versus-host disease after hematopoietic stem cell transplantation (2024)].《造血干细胞移植后急性移植物抗宿主病诊断与治疗中国专家共识(2024年版)》
Zhonghua Xue Ye Xue Za Zhi. 2024 Jun 14;45(6):525-533. doi: 10.3760/cma.j.cn121090-20240608-00214.
2
[Chinese expert consensus on the diagnosis and treatment of chronic graft-versus-host disease (2024)].《慢性移植物抗宿主病诊断与治疗中国专家共识(2024年版)》
Zhonghua Xue Ye Xue Za Zhi. 2024 Aug 14;45(8):713-726. doi: 10.3760/cma.j.cn121090-20240611-00217.
3
Acute Graft-Versus-Host Disease: A Brief Review.急性移植物抗宿主病:简要综述
Turk J Haematol. 2020 Feb 20;37(1):1-4. doi: 10.4274/tjh.galenos.2019.2019.0157. Epub 2019 Sep 2.
4
A study of conjunctival impression cytology in patients undergoing allogeneic hematopoietic stem cell transplantation and its relationship with Ocular Graft versus Host Disease.异基因造血干细胞移植患者结膜印迹细胞学研究及其与眼移植物抗宿主病的关系
Rom J Ophthalmol. 2025 Jan-Mar;69(1):68-73. doi: 10.22336/rjo.2025.12.
5
Interferon gamma release assay has potential in the prediction of chronic graft-versus-host disease in recipients of myeloablative allogeneic hematopoietic stem cell transplantation with post-transplantation cyclophosphamide-based graft-versus-host disease prophylaxis.干扰素γ释放试验在接受清髓性异基因造血干细胞移植并采用基于移植后环磷酰胺预防移植物抗宿主病的受者慢性移植物抗宿主病预测方面具有潜力。
Transpl Immunol. 2025 Feb;88:102166. doi: 10.1016/j.trim.2024.102166. Epub 2024 Dec 21.
6
Polyclonal anti-thymocyte globulins for the prophylaxis of graft-versus-host disease after allogeneic stem cell or bone marrow transplantation in adults.多克隆抗胸腺细胞球蛋白用于预防成人异基因干细胞或骨髓移植后的移植物抗宿主病。
Cochrane Database Syst Rev. 2012 Sep 12(9):CD009159. doi: 10.1002/14651858.CD009159.pub2.
7
Role of cytokines in the pathophysiology of acute graft-versus-host disease (GVHD): are serum/plasma cytokines potential biomarkers for diagnosis of acute GVHD following allogeneic hematopoietic cell transplantation (Allo-HCT)?细胞因子在急性移植物抗宿主病(GVHD)发病机制中的作用:血清/血浆细胞因子是否为异基因造血细胞移植(Allo-HCT)后诊断急性 GVHD 的潜在生物标志物?
Curr Stem Cell Res Ther. 2012 May;7(3):229-39. doi: 10.2174/157488812799859856.
8
[Acute and chronic graft-versus-host disease after allogeneic hematopoietic stem cell transplantation].[异基因造血干细胞移植后的急性和慢性移植物抗宿主病]
Rev Med Liege. 2022 May;77(5-6):345-353.
9
Ex Vivo CD34-Selected T Cell-Depleted Peripheral Blood Stem Cell Grafts for Allogeneic Hematopoietic Stem Cell Transplantation in Acute Leukemia and Myelodysplastic Syndrome Is Associated with Low Incidence of Acute and Chronic Graft-versus-Host Disease and High Treatment Response.用于急性白血病和骨髓增生异常综合征异基因造血干细胞移植的体外CD34选择的T细胞去除外周血干细胞移植物与急性和慢性移植物抗宿主病的低发生率及高治疗反应相关。
Biol Blood Marrow Transplant. 2017 Mar;23(3):452-458. doi: 10.1016/j.bbmt.2016.12.633. Epub 2016 Dec 23.
10
How does transfusion-associated graft-versus-host disease compare to hematopoietic cell transplantation-associated graft-versus-host disease?输血相关移植物抗宿主病与造血细胞移植相关移植物抗宿主病相比如何?
Transfus Apher Sci. 2022 Apr;61(2):103405. doi: 10.1016/j.transci.2022.103405. Epub 2022 Feb 17.

引用本文的文献

1
Ruxolitinib and decitabine plus a busulfan-cyclophosphamide conditioning regimen for relapse prophylaxis in patients with high-risk acute myeloid leukemia or myelodysplastic syndromes.芦可替尼与地西他滨联合白消安-环磷酰胺预处理方案用于高危急性髓系白血病或骨髓增生异常综合征患者的复发预防
Front Immunol. 2025 Aug 18;16:1586512. doi: 10.3389/fimmu.2025.1586512. eCollection 2025.
2
Management of infection and ocular complications in pediatric SJS/TEN-like acute graft-versus-host disease: a clinical case study and literature review.儿童类中毒性表皮坏死松解症/史蒂文斯-约翰逊综合征急性移植物抗宿主病感染及眼部并发症的管理:一项临床病例研究及文献综述
Front Immunol. 2025 Jun 16;16:1588297. doi: 10.3389/fimmu.2025.1588297. eCollection 2025.
3
Identification and validation of tissue-based gene biomarkers for acute intestinal graft-versus-host disease(AIGVHD).急性肠道移植物抗宿主病(AIGVHD)基于组织的基因生物标志物的鉴定与验证。
Front Immunol. 2025 May 13;16:1574904. doi: 10.3389/fimmu.2025.1574904. eCollection 2025.
4
The Aberrantly Expressed Nuclear Factor (Erythroid-derived 2)-Like 2 Participates in aGVHD by Modulating the Activation and Differentiation of CD4 + T Lymphocytes.异常表达的核因子(红系衍生2)样2通过调节CD4 + T淋巴细胞的激活和分化参与急性移植物抗宿主病。
Transplantation. 2025 Jul 1;109(7):1152-1165. doi: 10.1097/TP.0000000000005289. Epub 2025 Feb 7.
5
Umbilical Cord Blood Platelet Lysate Eyedrops for the Treatment of Severe Ocular Surface Disorders in Graft vs. Host Disease Patients: Clinical Study.脐带血血小板裂解液滴眼液治疗移植物抗宿主病患者严重眼表疾病的临床研究
Life (Basel). 2024 Oct 5;14(10):1268. doi: 10.3390/life14101268.

本文引用的文献

1
Mini-dose methotrexate combined with methylprednisolone for the initial treatment of acute GVHD: a multicentre, randomized trial.小剂量甲氨蝶呤联合甲基强的松龙治疗急性移植物抗宿主病的初步研究:一项多中心、随机试验。
BMC Med. 2024 Apr 25;22(1):176. doi: 10.1186/s12916-024-03395-y.
2
Mesenchymal stromal cells plus basiliximab improve the response of steroid-refractory acute graft-versus-host disease as a second-line therapy: a multicentre, randomized, controlled trial.间充质基质细胞加巴利昔单抗作为二线治疗改善激素难治性急性移植物抗宿主病的反应:一项多中心、随机、对照试验。
BMC Med. 2024 Feb 27;22(1):85. doi: 10.1186/s12916-024-03275-5.
3
Graft CD8 T-cell-based risk system predicts survival in antithymocyte globulin-based myeloablative haploidentical peripheral blood stem cell transplantation.基于移植物CD8 T细胞的风险系统可预测抗胸腺细胞球蛋白预处理的清髓性单倍体相合外周血干细胞移植的生存率。
Clin Transl Immunology. 2024 Jan 12;13(1):e1484. doi: 10.1002/cti2.1484. eCollection 2024.
4
Prophylaxis and management of graft-versus-host disease after stem-cell transplantation for haematological malignancies: updated consensus recommendations of the European Society for Blood and Marrow Transplantation.造血系统恶性肿瘤患者干细胞移植后移植物抗宿主病的预防和治疗:欧洲血液和骨髓移植学会更新的共识建议。
Lancet Haematol. 2024 Feb;11(2):e147-e159. doi: 10.1016/S2352-3026(23)00342-3. Epub 2024 Jan 3.
5
Longitudinal dynamics of gut microbiota in the pathogenesis of acute graft-versus-host disease.肠道微生物组在急性移植物抗宿主病发病机制中的纵向动力学。
Cancer Med. 2023 Dec;12(24):21567-21578. doi: 10.1002/cam4.6557. Epub 2023 Dec 6.
6
[Clinical analysis of sirolimus as an alternative GVHD prophylaxis for patients with kidney injury undergoing allo-HSCT].[西罗莫司作为肾损伤患者异基因造血干细胞移植替代移植物抗宿主病预防措施的临床分析]
Zhonghua Nei Ke Za Zhi. 2023 Dec 1;62(12):1444-1450. doi: 10.3760/cma.j.cn112138-20230306-00136.
7
Peripheral blood stem cell transplantation from haploidentical related donor could achieve satisfactory clinical outcomes for intermediate- or high-risk adult acute myeloid leukemia patients.对于中高危成人急性髓系白血病患者,来自单倍体相合相关供者的外周血造血干细胞移植可以获得满意的临床结果。
Bone Marrow Transplant. 2024 Feb;59(2):203-210. doi: 10.1038/s41409-023-02117-x. Epub 2023 Nov 15.
8
Mini-dose methotrexate combined with methylprednisolone as a first-line treatment for acute graft-versus-host disease: A phase 2 trial.小剂量甲氨蝶呤联合甲泼尼龙作为急性移植物抗宿主病的一线治疗:一项2期试验。
J Transl Int Med. 2023 Sep 2;11(3):255-264. doi: 10.2478/jtim-2023-0111. eCollection 2023 Sep.
9
Incidence, clinical presentation, risk factors, outcomes, and biomarkers in de novo late acute GVHD.初发迟发性急性移植物抗宿主病的发生率、临床表现、危险因素、结局和生物标志物。
Blood Adv. 2023 Aug 22;7(16):4479-4491. doi: 10.1182/bloodadvances.2023009885.
10
Acute graft-versus-host disease.急性移植物抗宿主病。
Nat Rev Dis Primers. 2023 Jun 8;9(1):27. doi: 10.1038/s41572-023-00438-1.