贝尔面瘫中乳酸脱氢酶、中性粒细胞与淋巴细胞比值、平均血小板体积及血小板与淋巴细胞比值的状况
Status of Lactate Dehydrogenase, Neutrophil-lymphocyte Ratio, Mean Platelet Volume, and Platelet-lymphocyte Ratio in Bell's Palsy.
作者信息
Baklacı Deniz, Guler İsmail, Kuzucu İhsan, Kum Rauf Oğuzhan, Özcan Müge
机构信息
Otolaryngology, Kahramankazan State Hospital, Ankara, TUR.
Otolaryngology, Medipol University School of Medicine, Ankara, TUR.
出版信息
Cureus. 2020 Mar 27;12(3):e7432. doi: 10.7759/cureus.7432.
OBJECTIVE
The inflammatory and vascular disorders have been proposed in the pathogenesis of Bell's palsy (BP). Several studies investigated the role of inflammation and ischemia in BP using white blood cell (WBC) count and its subtypes. Here, we aimed to investigate lactate dehydrogenase (LDH), neutrophil-lymphocyte ratio (NLR), mean platelet volume (MPV), and platelet-lymphocyte ratio (PLR) in BP.
METHODS
The study was conducted on 76 patients with BP and 60 healthy controls. The comparison of LDH, NLR, MPV, and PLR was made between groups. The relationships between LDH, NLR, MPV, and PLR were also investigated.
RESULTS
The mean LDH concentrations and NLR were significantly high in BP group than in control group (p < 0.01, p < 0.05, respectively). There was no significant difference between groups in MPV and PLR (p = 0.195, p = 0.263, respectively).
CONCLUSION
Our results support the diagnostic value of high LDH concentrations in BP patients. Further studies are needed to investigate the relationship between LDH and the severity and prognosis of BP.
目的
炎症和血管紊乱已被认为与贝尔面瘫（BP）的发病机制有关。多项研究利用白细胞（WBC）计数及其亚型，探究了炎症和缺血在BP中的作用。在此，我们旨在研究BP患者的乳酸脱氢酶（LDH）、中性粒细胞与淋巴细胞比值（NLR）、平均血小板体积（MPV）和血小板与淋巴细胞比值（PLR）。
方法
对76例BP患者和60例健康对照者进行了研究。比较了两组之间的LDH、NLR、MPV和PLR。还研究了LDH、NLR、MPV和PLR之间的关系。
结果
BP组的平均LDH浓度和NLR显著高于对照组（分别为p < 0.01，p < 0.05）。两组之间的MPV和PLR无显著差异（分别为p = 0.195，p = 0.263）。
结论
我们的结果支持高LDH浓度对BP患者的诊断价值。需要进一步研究来探究LDH与BP严重程度和预后之间的关系。
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