中性粒细胞与淋巴细胞比值和血小板平均体积对贝尔麻痹预后的影响：糖尿病与非糖尿病患者的比较。
Prognostic role of neutrophil lymphocyte ratio and mean platelet volume in Bell's palsy: Comparison of diabetic and non-diabetic patients.
机构信息
Baskent University, Faculty of Medicine, Department of Otolaryngology, Head and Neck Surgery, Ankara, Turkey.
Baskent University, Faculty of Medicine, Department of Otolaryngology, Head and Neck Surgery, Ankara, Turkey.
出版信息
Braz J Otorhinolaryngol. 2023 Jan-Feb;89(1):98-103. doi: 10.1016/j.bjorl.2021.10.003. Epub 2021 Nov 15.
OBJECTIVES
A low Neutrophil Lymphocyte Ratio (NLR) has been shown to be associated with good prognosis in Bell's Palsy (BP). However, the effect of chronic diseases that may affect the NLR, including Diabetes Mellitus (DM), has not been clarified in this context. This study aimed to evaluate the relationship between NLR and Mean Platelet Volume (MPV) in BP according to whether it is accompanied by DM, and their relationship with prognosis.
METHODS
A prospective observational study was conducted from May 2014 to May 2020 in a tertiary referral center, of all 79 consecutive participants diagnosed with BP in department of otolaryngology and 110 consecutive healthy participants admitted to the check-up unit. Patients diagnosed with BP were divided into two groups according to whether they were diagnosed with DM: diabetic BP patients (DM-BP, n = 33) and non-diabetic BP patients without any chronic disease (nonDM-BP, n = 46). Neutrophil (NEUT) and Lymphocyte (LYM) counts, and Mean Platelet Volume (MPV) were assessed from peripheral blood samples, and the NLR was calculated. Prognosis was evaluated using the House-Brackmann Score (HBS) six months after diagnosis.
RESULTS
The mean NLR was 2.85 ± 1.85 in BP patients and 1.69 ± 0.65 in the control group. The mean NLR was significantly higher in BP patients than healthy controls (p < 0.001). The mean NLR was 2.58 ± 1.83 in the nonDM-BP group, 3.23 ± 1.83 in the DM-BP group, and 1.69 ± 0.65 in the control group. The NLR was significantly higher in the nonDM-BP and DM-BP groups than in the control group (p < 0.05). The recovery was 90% according to the HBS. The optimal cut-off value was 2.41 (p = 0.5).
CONCLUSION
The NLR was increased in both diabetic and non-diabetic BP and had similar prognostic value in predicting the HBS before treatment in diabetic and non-diabetic patients with BP. MPV wasn't significantly different in diabetic and non-diabetic BP patients compared with the normal population.
目的
中性粒细胞与淋巴细胞比值（NLR）较低与贝尔面瘫（BP）的预后良好相关。然而，在这种情况下，包括糖尿病（DM）在内的可能影响 NLR 的慢性疾病的影响尚不清楚。本研究旨在根据是否伴有 DM 评估 NLR 和平均血小板体积（MPV）与 BP 的关系，并评估其与预后的关系。
方法
这是一项前瞻性观察研究，于 2014 年 5 月至 2020 年 5 月在耳鼻喉科的一个三级转诊中心进行，纳入了所有 79 名确诊为 BP 的连续患者和 110 名连续的健康体检者。根据是否诊断为 DM，将诊断为 BP 的患者分为两组：糖尿病 BP 患者（DM-BP，n=33）和无任何慢性疾病的非糖尿病 BP 患者（非 DM-BP，n=46）。从外周血样中评估中性粒细胞（NEUT）和淋巴细胞（LYM）计数和平均血小板体积（MPV），并计算 NLR。诊断后 6 个月，采用 House-Brackmann 评分（HBS）评估预后。
结果
BP 患者的平均 NLR 为 2.85±1.85，对照组为 1.69±0.65。BP 患者的平均 NLR 明显高于健康对照组（p<0.001）。非 DM-BP 组的平均 NLR 为 2.58±1.83，DM-BP 组为 3.23±1.83，对照组为 1.69±0.65。非 DM-BP 和 DM-BP 组的 NLR 明显高于对照组（p<0.05）。根据 HBS，恢复率为 90%。最佳截断值为 2.41（p=0.5）。
结论
在糖尿病和非糖尿病 BP 中，NLR 均升高，并且在预测糖尿病和非糖尿病 BP 患者治疗前 HBS 方面具有相似的预后价值。与正常人群相比，糖尿病和非糖尿病 BP 患者的 MPV 无显著差异。
Zotero 插件