Roscetti G, Ausiello C M, Palma C, Gulla P, Roda L G
Dipartimento di Medicina Sperimentale e Scienze Biochimiche, II Universita degli Studi di Roma, Tor Vergata, Rome, Italy.
Int J Immunopharmacol. 1988;10(7):819-23. doi: 10.1016/0192-0561(88)90005-7.
The effect of the two opioid pentapeptides met- and leu-enkephalin and of the tetrapeptide TYR-GLY-GLY-PHE on the stimulated proliferation of human peripheral blood mononucleate cells (PBMC) is described. Cell populations obtained from different donors were induced to proliferate with a Candida antigen. In the presence of the antigen, met-enkephalin and TYR-GLY-GLY-PHE had a concentration-dependent diphasic effect. The proliferation of PBMC was stimulated at high peptide concentration, while it was inhibited at the lower concentrations used. The effect of leu-enkephalin appears to be rather ambiguous, and directed towards the inhibition rather than the stimulation of PBMC proliferation.
本文描述了两种阿片类五肽（甲硫氨酸脑啡肽和亮氨酸脑啡肽）以及四肽TYR-GLY-GLY-PHE对人外周血单核细胞（PBMC）刺激增殖的影响。从不同供体获得的细胞群体用念珠菌抗原诱导增殖。在抗原存在的情况下，甲硫氨酸脑啡肽和TYR-GLY-GLY-PHE具有浓度依赖性双相效应。在高肽浓度下刺激PBMC增殖，而在较低浓度下则受到抑制。亮氨酸脑啡肽的作用似乎相当模糊，倾向于抑制而非刺激PBMC增殖。
