Epworth Centre for Innovation in Mental Health, Epworth HealthCare and Department of Psychiatry, Monash University, Melbourne, Victoria, Australia..
Psychiatry Res. 2020 Jun;288:112974. doi: 10.1016/j.psychres.2020.112974. Epub 2020 Apr 19.
Schizophrenia is characterised by delusions, hallucinations, anhedonia and apathy; while impairments in social cognition are often less recognised. Poor social cognition can lead to difficulties in obtaining and maintaining employment, academic progression, interpersonal relationships, and community functioning. Current interventions are highly intensive, require significant resources and have only modest effects on functional outcomes. Virtual reality (VR) and non-invasive brain stimulation (NIBS) may have a role in addressing these limitations. VR allows treatments that are potentially more accessible, less delivery intensive, and have higher ecological validity. While NIBS is able to directly modulate activity in social brain areas in order to promote neuroplasticity, strengthen neural connections and enhance brain function related to social cognitive behaviours. Therefore, the combination of VR and NIBS may allow for more efficient and transferrable interventions than those currently available. This review will explore the potential role of these technologies in the treatment of social cognitive impairment.
精神分裂症的特征是妄想、幻觉、快感缺失和冷漠；而社会认知障碍往往较少被认识到。较差的社会认知会导致在获得和维持就业、学业进步、人际关系和社区功能方面出现困难。目前的干预措施非常密集，需要大量资源，并且对功能结果的影响也不大。虚拟现实 (VR) 和非侵入性脑刺激 (NIBS) 可能在解决这些局限性方面发挥作用。VR 允许进行更具可及性、交付强度更低且具有更高生态有效性的治疗。而 NIBS 能够直接调节社会大脑区域的活动，以促进神经可塑性、增强神经连接和增强与社会认知行为相关的大脑功能。因此，与目前可用的治疗方法相比，VR 和 NIBS 的结合可能会带来更高效和更可转移的干预措施。本综述将探讨这些技术在治疗社会认知障碍方面的潜在作用。
