Wisecarver J, Harrington D
Department of Pathology and Microbiology, University of Nebraska Medical Center, Omaha, Nebraska 68105.
Hematol Pathol. 1988;2(1):51-4.
Bone marrow necrosis is a rare and ominous complication of hematologic malignancy which is often associated with bone pain in the lower back and extremities. Widespread marrow necrosis makes a definitive diagnosis through bone marrow biopsy difficult. An accurate diagnosis is imperative in patients with promyelocytic leukemia (FAB-M3) because disseminated intravascular coagulation and hemorrhage secondary to release of tissue thromboplastins from the malignant cell population requires prompt and anticipatory therapy. The following case report describes a patient with acute leukemia and massive bone marrow necrosis which obscured the correct diagnosis of promyelocytic leukemia.
骨髓坏死是血液系统恶性肿瘤一种罕见且凶险的并发症，常伴有下背部和四肢骨痛。广泛的骨髓坏死使得通过骨髓活检进行明确诊断变得困难。对于早幼粒细胞白血病（FAB-M3）患者，准确诊断至关重要，因为恶性细胞群释放组织凝血活酶继发的弥散性血管内凝血和出血需要及时且有前瞻性的治疗。以下病例报告描述了一名患有急性白血病和大量骨髓坏死的患者，这掩盖了早幼粒细胞白血病的正确诊断。
