Laboratory of Integrative Biology (LIBi), Center of Excellence in Translational Medicine- Scientific and Technological Bioresource Nucleus (CEMT-BIOREN), Universidad de La Frontera, Temuco 4710296, Chile.
Instituto de Ciencias Biomédicas, Facultad de Ciencias de la Salud, Universidad Autónoma de Chile, Temuco 4810101, Chile.
Mar Drugs. 2020 Apr 28;18(5):232. doi: 10.3390/md18050232.
Fucoidans are sulphated polysaccharides that can be obtained from brown seaweed and marine invertebrates. They have anti-cancer properties, through their targeting of several signaling pathways and molecular mechanisms within malignant cells. This review describes the chemical structure diversity of fucoidans and their similarity with other molecules such as glycosaminoglycan, which enable them to participation in diverse biological processes. Furthermore, this review summarizes their influence on the development of metastasis and drug resistance, which are the main obstacles to cure cancer. Finally, this article discusses how fucoidans have been used in clinical trials to evaluate their potential synergy with other anti-cancer therapies.
褐藻胶是一种硫酸多糖，可从褐藻和海洋无脊椎动物中获得。它们具有抗癌特性，通过靶向恶性细胞内的几种信号通路和分子机制。本综述描述了褐藻胶的化学结构多样性及其与其他分子（如糖胺聚糖）的相似性，使其能够参与多种生物过程。此外，本综述总结了它们对转移和耐药性发展的影响，这是治愈癌症的主要障碍。最后，本文讨论了褐藻胶如何在临床试验中被用于评估它们与其他抗癌疗法联合使用的潜力。
