Rajendran Arunraj Tharamelveliyil, Vadakkepushpakath Anoop Narayanan
Department of Pharmaceutics, NGSM Institute of Pharmaceutical Sciences (NGSMIPS), Nitte (Deemed to be University), Mangalore 575018, Karnataka, India.
Foods. 2024 Sep 4;13(17):2812. doi: 10.3390/foods13172812.
Efficient drug delivery methods are crucial in modern pharmacotherapy to enhance treatment efficacy, minimize adverse effects, and improve patient compliance. Particularly in the context of glioblastoma treatment, there has been a recent surge in interest in using natural dietary components as innovative carriers for drug delivery. These food-derived carriers, known for their safety, biocompatibility, and multifunctional properties, offer significant potential in overcoming the limitations of conventional drug delivery systems. This article thoroughly overviews numerous natural dietary components, such as polysaccharides, proteins, and lipids, used as drug carriers. Their mechanisms of action, applications in different drug delivery systems, and specific benefits in targeting glioblastoma are examined. Additionally, the safety, biocompatibility, and regulatory considerations of employing food components in drug formulations are discussed, highlighting their viability and future prospects in the pharmaceutical field.
高效的药物递送方法在现代药物治疗中至关重要,有助于提高治疗效果、将不良反应降至最低并提高患者的依从性。特别是在胶质母细胞瘤治疗方面,最近人们对使用天然膳食成分作为药物递送的创新载体兴趣大增。这些源自食物的载体以其安全性、生物相容性和多功能特性而闻名,在克服传统药物递送系统的局限性方面具有巨大潜力。本文全面概述了用作药物载体的多种天然膳食成分,如多糖、蛋白质和脂质。研究了它们的作用机制、在不同药物递送系统中的应用以及在靶向胶质母细胞瘤方面的具体益处。此外,还讨论了在药物制剂中使用食品成分的安全性、生物相容性和监管考量,突出了它们在制药领域的可行性和未来前景。