Bajpai P K, Benghuzzi H A
Department of Biology, University of Dayton, Ohio 45469.
J Biomed Mater Res. 1988 Dec;22(12):1245-66. doi: 10.1002/jbm.820221212.
Evaluation of devices, drugs, and drug delivery systems have been investigated by both in vitro and in vivo procedures. Ceramic drug delivery systems can be used to evaluate chemicals and biologicals by both in vitro and in vivo procedures. The system can also reduce handling of the animals and facilitate long-term evaluations before conducting clinical trials. To date, ceramic systems have been used to deliver aldosterone, androstanedione, beta-lactoglobulin, bovine serum albumin, chymotrypsin, danazol, difluoromeythylornithine, dihydrotestosterone, estradiol, gamma globulin, gonadotrophic releasing hormone, gossypol, growth hormone, insulin, methylene blue, pepsin, progesterone, and testosterone. The data obtained suggest that ceramic delivery systems can be used in the near future to treat diseases requiring long-term chronic drug therapy as well as disorders caused by deficiency of certain hormones.
已经通过体外和体内程序对设备、药物和药物递送系统进行了评估。陶瓷药物递送系统可用于通过体外和体内程序评估化学物质和生物制品。该系统还可以减少动物的处理，并便于在进行临床试验之前进行长期评估。迄今为止，陶瓷系统已用于递送醛固酮、雄甾烷二酮、β-乳球蛋白、牛血清白蛋白、胰凝乳蛋白酶、达那唑、二氟甲基鸟氨酸、二氢睾酮、雌二醇、γ-球蛋白、促性腺激素释放激素、棉酚、生长激素、胰岛素、亚甲蓝、胃蛋白酶、孕酮和睾酮。获得的数据表明，陶瓷递送系统在不久的将来可用于治疗需要长期慢性药物治疗的疾病以及由某些激素缺乏引起的病症。
