合成羟基磷灰石、β-磷酸三钙和双相磷酸钙颗粒作为姜黄素的局部递送载体：负载、释放及体外研究

Synthesis of Hydroxyapatite, β-Tricalcium Phosphate and Biphasic Calcium Phosphate Particles to Act as Local Delivery Carriers of Curcumin: Loading, Release and In Vitro Studies.

作者信息

Xidaki Despoina, Agrafioti Panagiota, Diomatari Dimitra, Kaminari Archontia, Tsalavoutas-Psarras Eleftherios, Alexiou Polyxeni, Psycharis Vasilios, Tsilibary Effie C, Silvestros Spyridon, Sagnou Marina

机构信息

STEP@biomaterials PC, Department of Research & Development, TEPA "Lefkippos", Patriarchou Grigoriou & Neapoleos 27, 153 41 Agia Paraskevi, Athens, Greece.

Dental School, National and Kapodistrian University of Athens, Thivon 2, 115 27 Goudi, Athens, Greece.

出版信息

Materials (Basel). 2018 Apr 12;11(4):595. doi: 10.3390/ma11040595.

The successful synthesis of hydroxyapatite (HA), β-Tricalcium phosphate (β-TCP) and two biphasic mixtures (BCPs) of the two was performed by means of wet precipitation. The resulting crystals were characterized and the BCP composition was analyzed and identified as 13% HA-87% TCP and 41% HA-59% TCP. All samples were treated with curcumin solutions, and the degree of curcumin loading and release was found to be proportional to the TCP content of the ceramic. No further cytotoxicity was observed upon MG-63 treatment with the curcumin-loaded ceramics. Finally, the alkaline phosphatase activity of the cells was found to increase with increasing content of TCP, which provides an encouraging proof of concept for the use of curcumin-loaded synthetic biomaterials in bone remodeling.